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Editorial
. 2022 Apr 21;139(16):2418-2420.
doi: 10.1182/blood.2021015364.

Firing up chromatin to forge T-ALL

Mark Y Chiang  1
Affiliations
Editorial

Firing up chromatin to forge T-ALL

Mark Y Chiang. Blood. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflict-of-interest disclosure: The author declares no competing financial interests.

Figures

None
Model depicting the genome-scale actions of T-cell factor 1 (Tcf1) in promoting chromatin accessibility for T-cell development and leukemogenesis. Physiological Notch signaling directs Tcf1 to displace nucleosomes, paving the way for additional transcription factors to bind and induce T-cell differentiation genes. In contrast, supraphysiological Notch signaling directs Tcf1 to open a newly appreciated myelocytomatosis protooncogene (Myc) enhancer (TMe) that transforms Notch actions from physiological to oncogenic. HSC, hematopoietic stem cell. See the visual abstract in the article by Antoszewski et al that begins on page 2483.
See this image and copyright information in PMC

Comment on

  • Tcf1 is essential for initiation of oncogenic Notch1-driven chromatin topology in T-ALL.
    Antoszewski M, Fournier N, Ruiz Buendía GA, Lourenco J, Liu Y, Sugrue T, Dubey C, Nkosi M, Pritchard CEJ, Huijbers IJ, Segat GC, Alonso-Moreno S, Serracanta E, Belver L, Ferrando AA, Ciriello G, Weng AP, Koch U, Radtke F. Antoszewski M, et al. Blood. 2022 Apr 21;139(16):2483-2498. doi: 10.1182/blood.2021012077. Blood. 2022. PMID: 35020836 Free PMC article.

References

    1. Antoszewski M, Fournier N, Ruiz Buendía GA, et al. . Tcf1 is essential for initiation of oncogenic Notch1-driven chromatin topology in T-ALL. Blood. 2022;139(16):2483-2498. - PMC - PubMed
    1. Radtke F, Wilson A, Stark G, et al. . Deficient T cell fate specification in mice with an induced inactivation of Notch1. Immunity. 1999;10(5):547-558. - PubMed
    1. Weng AP, Ferrando AA, Lee W, et al. . Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science. 2004;306(5694):269-271. - PubMed
    1. McCarter AC, Wang Q, Chiang M. Notch in leukemia. Adv Exp Med Biol. 2018;1066:355-394. - PubMed
    1. Johnson JL, Georgakilas G, Petrovic J, et al. . Lineage-determining transcription factor TCF-1 initiates the epigenetic identity of T cells. Immunity. 2018;48(2):243-257.e10. - PMC - PubMed

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