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. 2022 Apr 15;10(4):70.
doi: 10.3390/dj10040070.

Salivary Scca1, Scca2 and Trop2 in Oral Cancer Patients-A Cross-Sectional Pilot Study

Ivana Karmelić  1 , Ivan Salarić  2   3 , Ksenija Baždarić  4 , Marko Rožman  5 , Ivan Zajc  1   2 , Marinka Mravak-Stipetić  6 , Ivona Bago  7 , Davor Brajdić  2   3 , Jasna Lovrić  1 , Darko Macan  2   3
Affiliations

Salivary Scca1, Scca2 and Trop2 in Oral Cancer Patients-A Cross-Sectional Pilot Study

Ivana Karmelić et al. Dent J (Basel). .

Abstract

Oral squamous cell carcinoma (OSCC) is frequently diagnosed in the advanced stages. The purpose of this paper is to determine the salivary values of SCCA1, SCCA2 and TROP2 in patients with T1N0M0 OSCC and to compare them with the values obtained from healthy individuals. Unstimulated (UWS) and stimulated (SWS) saliva was sampled from 29 patients with T1N0M0 OSCC and 29 sex- and age-matched healthy individuals. Statistical difference was observed in SCCA1 and SCCA2 levels both in UWS and SWS samples. TROP2 was not measurable in most of the salivary samples. Both SCCA1 and SCCA2 could represent potential biomarkers for the early-stage OSCC. Research on a larger sample and biomarker validation is needed to assess the clinical potential of SCCA1 and SCCA2 in the OSCC early diagnostics.

Keywords: biomarkers; early diagnosis; oral cancer; saliva.

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Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.

Figures

Figure 1
Figure 1
SCCA1 levels (pg/mL) in unstimulated whole saliva (UWS) and stimulated whole saliva (SWS) in patients with oral squamous cell carcinoma (OSCC) and in the control group expressed with median and the 25th–75th percentiles.
Figure 2
Figure 2
SCCA2 levels (pg/mL) in unstimulated whole saliva (UWS) and stimulated whole saliva (SWS) in patients with oral squamous cell carcinoma (OSCC) and in the control group expressed with median and the 25th–75th percentiles.
See this image and copyright information in PMC

References

    1. Sung H., Ferlay J., Siegel R.L., Laversanne M., Soerjomataram I., Jemal A., Bray F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J. Clin. 2021;71:209–249. doi: 10.3322/caac.21660. - DOI - PubMed
    1. Ma’Aita J.K. Oral cancer in Jordan: A retrospective study of 118 patients. Croat. Med. J. 2000;41:64–69. - PubMed
    1. Radman M., Glavina A., Sabol I., Mravak-Stipetić M. Knowledge of Oral Cancer among the Fourth and Fifth Year Dental Students. Acta Stomatol. Croat. 2018;52:340–347. doi: 10.15644/asc52/4/8. - DOI - PMC - PubMed
    1. Shao Y., Song Y., Xu S., Li S., Zhou H. Expression Profile of Circular RNAs in Oral Squamous Cell Carcinoma. Front. Oncol. 2020;10:1–12. doi: 10.3389/fonc.2020.533616. - DOI - PMC - PubMed
    1. Derakhshan S., Poosti A., Razavi A.E., Moosavi M.A., Mahdavi N., Naieni F.B., Hesari K.K., Rahpeima A. Evaluation of squamous cell carcinoma antigen 1 expression in oral squamous cell carcinoma (tumor cells and peritumoral T-lymphocytes) and verrucous carcinoma and comparison with normal oral mucosa. J. Appl. Oral Sci. 2021;29:e20210374. doi: 10.1590/1678-7757-2021-0374. - DOI - PMC - PubMed