Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Apr 16;9(4):120.
doi: 10.3390/jcdd9040120.

Implantable Cardioverter Defibrillator in Primary and Secondary Prevention of SCD-What We Still Don't Know

Affiliations
Review

Implantable Cardioverter Defibrillator in Primary and Secondary Prevention of SCD-What We Still Don't Know

Andreea Maria Ursaru et al. J Cardiovasc Dev Dis. .

Abstract

Implantable cardioverter defibrillators (ICDs) are the cornerstone of primary and secondary prevention of sudden cardiac death (SCD) all around the globe. In almost 40 years of technological advances and multiple clinical trials, there has been a continuous increase in the implantation rate. The purpose of this review is to highlight the grey areas related to actual ICD recommendations, focusing specifically on the primary prevention of SCD. We will discuss the still-existing controversies strongly reflected in the differences between the international guidelines regarding ICD indication class in non-ischemic cardiomyopathy, and also address the question of early implantation after myocardial infarction in the absence of clear protocols for patients at high risk of life-threatening arrhythmias. Correlating the insufficient data in the literature for 40-day waiting times with the increased risk of SCD in the first month after myocardial infarction, we review the pros and cons of early ICD implantation.

Keywords: early ICD implantation; implantable cardioverter defibrillator; ischemic cardiomyopathy; myocardial infarction; non-ischemic cardiomyopathy; primary prevention; secondary prevention; sudden cardiac death.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there is no conflict of interest.

References

    1. Mendis S., Puska P., Norrving B., World Health Organization . Global Atlas on Cardiovascular Disease Prevention and Control. World Health Organization; Geneva, Switzerland: 2011.
    1. Kamp N.J., Al-Khatib S.M. The subcutaneous implantable cardioverter-defibrillator in review. Am. Heart J. 2019;217:131–139. doi: 10.1016/j.ahj.2019.08.010. - DOI - PubMed
    1. Virani S.S., Alonso A., Aparicio H.J., Benjamin E.J., Bittencourt M.S., Callaway C.W., Carson A.P., Chamberlain A.M., Cheng S., Delling F.N., et al. Heart Disease and Stroke Statistics-2021 Update: A Report From the American Heart Association. Circulation. 2021;143:e254–e743. doi: 10.1161/CIR.0000000000000950. - DOI - PubMed
    1. Al-Khatib S.M., Stevenson W.G., Ackerman M.J., Bryant W.J., Callans D.J., Curtis A.B., Deal B.J., Dickfeld T., Field M.E., Fonarow G.C., et al. 2017 AHA/ACC/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: A report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. J. Am. Coll. Cardiol. 2018;72:91–220. - PubMed
    1. Goldberger J.J., Buxton A.E., Cain M., Costantini O., Exner D.V., Knight B.P., Lloyd-Jones D., Kadish A.H., Lee B., Moss A., et al. Risk stratification for arrhythmic sudden cardiac death: Identifying the roadblocks. Circulation. 2011;123:2423–2430. doi: 10.1161/CIRCULATIONAHA.110.959734. - DOI - PubMed

LinkOut - more resources