Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2022 Jun;18(6):321-322.
doi: 10.1038/s41582-022-00661-6.

Brain changes after COVID-19 - how concerned should we be?

Stéphane Kremer  1   2 , H Rolf Jäger  3   4
Affiliations
Comment

Brain changes after COVID-19 - how concerned should we be?

Stéphane Kremer et al. Nat Rev Neurol. 2022 Jun.

Abstract

Analysis of brain images taken before and after infection with SARS-CoV-2 suggests that even mild COVID-19 is associated with brain structure alterations and cognitive impairment. However, the clinical implications for individuals are unclear and further studies are needed to assess the generalizability of the findings and whether the effects are long-lasting.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Comment on

  • SARS-CoV-2 is associated with changes in brain structure in UK Biobank.
    Douaud G, Lee S, Alfaro-Almagro F, Arthofer C, Wang C, McCarthy P, Lange F, Andersson JLR, Griffanti L, Duff E, Jbabdi S, Taschler B, Keating P, Winkler AM, Collins R, Matthews PM, Allen N, Miller KL, Nichols TE, Smith SM. Douaud G, et al. Nature. 2022 Apr;604(7907):697-707. doi: 10.1038/s41586-022-04569-5. Epub 2022 Mar 7. Nature. 2022. PMID: 35255491 Free PMC article.

References

    1. Douaud G, et al. SARS-CoV-2 is associated with changes in brain structure in UK Biobank. Nature. 2022 doi: 10.1038/s41586-022-04569-5. - DOI - PMC - PubMed
    1. Salomon T, et al. Brain volumetric changes in the general population following the COVID-19 outbreak and lockdown. Neuroimage. 2021;239:118311. doi: 10.1016/j.neuroimage.2021.118311. - DOI - PubMed
    1. Renaud M, et al. Clinical outcomes for patients with anosmia 1 year after COVID-19 diagnosis. JAMA Netw. Open. 2021;4:e2115352. doi: 10.1001/jamanetworkopen.2021.15352. - DOI - PMC - PubMed
    1. Ferrucci R, et al. One-year cognitive follow-up of COVID-19 hospitalized patients. Eur. J. Neurol. 2022 doi: 10.1111/ene.15324. - DOI - PMC - PubMed
    1. Zubair AS, et al. Neuropathogenesis and neurologic manifestations of the coronaviruses in the age of coronavirus disease 2019: a review. JAMA Neurol. 2020;77:1018–1027. doi: 10.1001/jamaneurol.2020.2065. - DOI - PMC - PubMed