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Meta-Analysis
. 2022 Apr 11:2022:3254586.
doi: 10.1155/2022/3254586. eCollection 2022.

Comparison of Clinical Efficacy and Safety between Misoprostol and Oxytocin in the Prevention of Postpartum Hemorrhage: A Meta-Analysis

Renmei Xu  1 , Yongjie Guo  1 , Qinggui Zhang  1 , Xiaokang Zeng  2
Affiliations
Meta-Analysis

Comparison of Clinical Efficacy and Safety between Misoprostol and Oxytocin in the Prevention of Postpartum Hemorrhage: A Meta-Analysis

Renmei Xu et al. J Healthc Eng. .

Retraction in

Abstract

In order to systematically evaluate the clinical efficacy and safety of misoprostol versus oxytocin in the prevention of postpartum hemorrhage, this paper provides evidence-based reference for clinical medication, computerized retrieval of Chinese biomedical literature database (CBM), PubMed, Embase, Cochrane Library, and clinical trials. The retrieval period is from the establishment of each database to October 1, 2021. Published randomized controlled trials (RCTS) are included in this study. The literature is screened and evaluated according to inclusion and exclusion criteria, and meta-analysis is performed using RevMan 5.3 software. A total of 13 RCTS are included, with a total of 24754 parturients. The meta-analysis shows the average blood loss (SMD = 0.10, 95% CI (-0.11, 0.32), P=0.35), the time of the third stage of labor (SMD = 0, 95% CI (-0.07, 0.08), P=0.95), and blood transfusion rate (RR = 0.80, 95% CI (0.63, 1.02), P=0.07). However, the incidences of shivering (RR = 2.61, 95% CI (1.79, 0.81), P < 0.00001) and vomiting (RR = 2.78, 95% CI (1.85, 4.18), P < 0.00001) are significantly higher than those in oxytocin group. The effect of misoprostol on preventing postpartum hemorrhage is similar to that of oxytocin, but the incidence of adverse reactions is high, and the occurrence of adverse reactions should be closely watched in the use process. Due to the limitations of the included studies, multicenter, large-sample, and high-quality RCTS are still needed in the future to further verify this conclusion.

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Conflict of interest statement

The authors declare that there are no conflicts of interest regarding the publication of this paper.

Figures

Figure 1
Figure 1
PRISMA flowchart for our literature search.
Figure 2
Figure 2
Risk of bias summary and risk of bias graph.
Figure 3
Figure 3
The pooled standard mean difference of blood loss for 7 studies.
Figure 4
Figure 4
The pooled standard mean difference of the time of the third stage of labor for 5 studies.
Figure 5
Figure 5
The pooled rate of blood transfusion for 9 studies.
Figure 6
Figure 6
The pooled rate of shivering for 9 studies.
Figure 7
Figure 7
The pooled rate of vomiting for 9 studies.
Figure 8
Figure 8
The funnel plot for publication bias.
See this image and copyright information in PMC

References

    1. Bienstock J. L., Eke A. C., Hueppchen N. A. Postpartum hemorrhage. New England Journal of Medicine . 2021;384(17):1635–1645. doi: 10.1056/nejmra1513247. - DOI - PMC - PubMed
    1. Ende H. B., Lozada M. J., Chestnut D. H., et al. Risk factors for atonic postpartum hemorrhage. Obstetrics & Gynecology . 2021;137(2):305–323. doi: 10.1097/aog.0000000000004228. - DOI - PMC - PubMed
    1. Neary C., Naheed S., McLernon D., Black M. Predicting risk of postpartum haemorrhage: a systematic review. BJOG: An International Journal of Obstetrics and Gynaecology . 2021;128(1):46–53. doi: 10.1111/1471-0528.16379. - DOI - PubMed
    1. Ende H. B., Butwick A. J. Current state and future direction of postpartum hemorrhage risk assessment. Obstetrics & Gynecology . 2021;138(6):924–930. doi: 10.1097/aog.0000000000004579. - DOI - PubMed
    1. Althabe F., Therrien M. N. S., Pingray V., et al. Postpartum hemorrhage care bundles to improve adherence to guidelines: AWHOtechnical consultation. International Journal of Gynecology & Obstetrics . 2020;148(3):290–299. doi: 10.1002/ijgo.13028. - DOI - PMC - PubMed

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