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. 2022 May;28(5):924-931.
doi: 10.3201/eid2805.212535.

Genomic Epidemiology of Global Carbapenemase-Producing Escherichia coli, 2015-2017

Gisele Peirano, Liang Chen, Diego Nobrega, Thomas J Finn, Barry N Kreiswirth, Rebekah DeVinney, Johann D D Pitout

Genomic Epidemiology of Global Carbapenemase-Producing Escherichia coli, 2015-2017

Gisele Peirano et al. Emerg Infect Dis. 2022 May.

Abstract

We describe the global molecular epidemiology of 229 carbapenemase-producing Escherichia coli in 36 countries during 2015-2017. Common carbapenemases were oxacillinase (OXA) 181 (23%), New Delhi metallo-β-lactamase (NDM) 5 (20%), OXA-48 (17%), Klebsiella pneumoniae carbapenemase 2 (15%), and NDM-1 (10%). We identified 5 dominant sequence types (STs); 4 were global (ST410, ST131, ST167, and ST405), and 1 (ST1284) was limited to Turkey. OXA-181 was frequent in Jordan (because of the ST410-B4/H24RxC subclade) and Turkey (because of ST1284). We found nearly identical IncX3-blaOXA-181 plasmids among 11 STs from 12 countries. NDM-5 was frequent in Egypt, Thailand (linked with ST410-B4/H24RxC and ST167-B subclades), and Vietnam (because of ST448). OXA-48 was common in Turkey (linked with ST11260). Global K. pneumoniae carbapenemases were linked with ST131 C1/H30 subclade and NDM-1 with various STs. The global carbapenemase E. coli population is dominated by diverse STs with different characteristics and varied geographic distributions, requiring ongoing genomic surveillance.

Keywords: AMR; E. coli; Escherichia coli; antimicrobial resistance; bacteria; carbapenemases; molecular epidemiology; surveillance; whole-genome sequencing.

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