Subjective cognitive decline and stage 2 of Alzheimer disease in patients from memory centers

Frank Jessen^{1

2}, Steffen Wolfsgruber^{1

3}, Luca Kleineindam^{1

3}, Annika Spottke^{1

4}, Slawek Altenstein^{5

6}, Claudia Bartels⁷, Moritz Berger⁸, Frederic Brosseron¹, Marcel Daamen^{1

9}, Martin Dichgans^{10

11}, Laura Dobisch^{12

13}, Michael Ewers¹¹, Friederike Fenski¹⁴, Klaus Fliessbach³, Silka D Freiesleben¹⁴, Wenzel Glanz^{12

13}, Doreen Görß^{15

16}, Selim Gürsel¹⁷, Daniel Janowitz¹¹, Ingo Kilimann^{15

16}, Xenia Kobeleva³, Andrea Lohse⁶, Franziska Maier², Coraline Metzger^{12

13}, Matthias Munk¹⁸, Lukas Preis¹⁴, Carolin Sanzenbacher¹⁸, Eike Spruth⁶, Boris Rauchmann¹⁷, Ruth Vukovich⁷, Renat Yakupov^{12

13}, Anne-Sophie Weyrauch^{1

3}, Gabriel Ziegler^{12

13}, Matthias Schmid^{1

8}, Christoph Laske^{19

20}, Robert Perneczky^{10

17}, Anja Schneider^{1

3}, Jens Wiltfang^{7

20}, Stefan Teipel^{15

16}, Katharina Bürger^{10

11}, Josef Priller^{5

6}, Oliver Peters^{5

14}, Alfredo Ramirez^{1

2

3}, Henning Boecker^{1

9}, Michael T Heneka^{1

3}, Michael Wagner^{1

3}, Emrah Düzel^{12

13}

Affiliations

¹ German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
² Department of Psychiatry, University of Cologne, Medical Faculty, Cologne, Germany.
³ Department of Neurodegenerative Diseases and Gerontopsychiatry, University of Bonn, Bonn, Germany.
⁴ Department of Neurology, University of Bonn, Bonn, Germany.
⁵ German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.
⁶ Department of Neuropsychiatry, Charité-Universitätsmedizin Berlin, Berlin, Germany.
⁷ Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen, Germany.
⁸ Institute for Medical Biometry, University of Bonn, Bonn, Germany.
⁹ Department of Radiology, University of Bonn, Bonn, Germany.
¹⁰ German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
¹¹ Institute for Stroke and Dementia Research, Klinikum der Universität München, Munich, Germany.
¹² German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.
¹³ Institute for Cognitive Neurology and Dementia Research, University of Magdeburg, Magdeburg, Germany.
¹⁴ Department of Psychiatry and Psychotherapy, Charité, Berlin, Germany.
¹⁵ German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany.
¹⁶ Department of Psychosomatic Medicine, University of Rostock, Rostock, Germany.
¹⁷ Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, München, Germany.
¹⁸ Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany.
¹⁹ German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
²⁰ German Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany.

PMID: 35451563
DOI: 10.1002/alz.12674

Multicenter Study

Subjective cognitive decline and stage 2 of Alzheimer disease in patients from memory centers

Frank Jessen et al. Alzheimers Dement. 2023 Feb.

. 2023 Feb;19(2):487-497.

doi: 10.1002/alz.12674. Epub 2022 Apr 22.

Authors

Affiliations

¹ German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
² Department of Psychiatry, University of Cologne, Medical Faculty, Cologne, Germany.
³ Department of Neurodegenerative Diseases and Gerontopsychiatry, University of Bonn, Bonn, Germany.
⁴ Department of Neurology, University of Bonn, Bonn, Germany.
⁵ German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.
⁶ Department of Neuropsychiatry, Charité-Universitätsmedizin Berlin, Berlin, Germany.
⁷ Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen, Germany.
⁸ Institute for Medical Biometry, University of Bonn, Bonn, Germany.
⁹ Department of Radiology, University of Bonn, Bonn, Germany.
¹⁰ German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
¹¹ Institute for Stroke and Dementia Research, Klinikum der Universität München, Munich, Germany.
¹² German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.
¹³ Institute for Cognitive Neurology and Dementia Research, University of Magdeburg, Magdeburg, Germany.
¹⁴ Department of Psychiatry and Psychotherapy, Charité, Berlin, Germany.
¹⁵ German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany.
¹⁶ Department of Psychosomatic Medicine, University of Rostock, Rostock, Germany.
¹⁷ Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, München, Germany.
¹⁸ Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany.
¹⁹ German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
²⁰ German Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany.

PMID: 35451563
DOI: 10.1002/alz.12674

Abstract

Introduction: It is uncertain whether subjective cognitive decline (SCD) in individuals who seek medical help serves the identification of the initial symptomatic stage 2 of the Alzheimer's disease (AD) continuum.

Methods: Cross-sectional and longitudinal data from the multicenter, memory clinic-based DELCODE study.

Results: The SCD group showed slightly worse cognition as well as more subtle functional and behavioral symptoms than the control group (CO). SCD-A+ cases (39.3% of all SCD) showed greater hippocampal atrophy, lower cognitive and functional performance, and more behavioral symptoms than CO-A+. Amyloid concentration in the CSF had a greater effect on longitudinal cognitive decline in SCD than in the CO group.

Discussion: Our data suggests that SCD serves the identification of stage 2 of the AD continuum and that stage 2, operationalized as SCD-A+, is associated with subtle, but extended impact of AD pathology in terms of neurodegeneration, symptoms and clinical progression.

Keywords: Alzheimer's disease; amyloid beta 42; apolipoprotein E; cerebrospinal fluid; longitudinal; magnetic resonance imaging; mild cognitive impairment; positron emission tomography; subjective cognitive decline; tau.

PubMed Disclaimer

References

REFERENCES

1. van der Flier WM, Scheltens P. Amsterdam dementia cohort: Performing research to optimize care. J Alzheimers Dis. 2018;62:1091-1111.
1. Garcia-Ptacek S, Cavallin L, Kåreholt I, et al. Subjective cognitive impairment subjects in our clinical practice. Dement Geriatr Cogn Dis Extra. 2014;4:419-430.
1. Jessen F, Amariglio RE, van Boxtel M, et al. A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease. Alzheimers Dement. 2014;10:844-852.
1. Slot RER, Sikkes SAM, Berkhof J, et al. Subjective cognitive decline and rates of incident Alzheimer's disease and non-Alzheimer's disease dementia. Alzheimers Dement. 2019;15:465-476.
1. Pike KE, Cavuoto MG, Li L, Wright BJ, Kinsella GJ. Subjective cognitive decline: Level of risk for future dementia and mild cognitive impairment, a meta-analysis of longitudinal studies. Neuropsychol Rev. 2021;https://doi.org/10.1007/s11065-021-09522-3. Epub ahead of print

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions

Associated data

DRKS/DRKS00007966

LinkOut - more resources

Full Text Sources
- Ovid Technologies, Inc.
- Wiley
Medical
- MedlinePlus Health Information

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Subjective cognitive decline and stage 2 of Alzheimer disease in patients from memory centers

Affiliations

Subjective cognitive decline and stage 2 of Alzheimer disease in patients from memory centers

Authors

Affiliations

Abstract

References

REFERENCES

Publication types

MeSH terms

Substances

Associated data

LinkOut - more resources

Full Text Sources

Medical