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Review
. 2022 Jun;129(5-6):611-615.
doi: 10.1007/s00702-022-02496-3. Epub 2022 Apr 22.

Failed regeneration and inflammation in schizophrenia: two sides of the same coin?

Peter Falkai  1 , Andrea Schmitt  2   3
Affiliations
Review

Failed regeneration and inflammation in schizophrenia: two sides of the same coin?

Peter Falkai et al. J Neural Transm (Vienna). 2022 Jun.

Abstract

More than 100 years after its conceptual definition as 'Dementia Praecox' by Emil Kraepelin, which was changed to schizophrenia by Eugen Bleuler, this is still a serious and debilitating psychiatric illness. The neurodevelopmental hypothesis of schizophrenia, introduced more than 30 years ago, states that schizophrenia is a consequence of failed neurodevelopmental processes leading to a dysfunctional neuronal network forming the basis for a psychosis proneness. Subsequently, significant research efforts were made to prove the neurodevelopmental or the neurodegenerative perspective. This review summarizes key arguments speaking for or against the two hypotheses leading to a concept with both aspects position side by side.

Keywords: Interneuron; Neurodegeneration; Neurodevelopment; Neuroinflammation; Neuron; Oligodendrocyte; Schizophrenia.

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Figures

Fig. 1
Fig. 1
Stratifying Schizophrenia based on its long-term course (Häfner 2003)
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