Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1978 Jun;13(6):914-7.
doi: 10.1128/AAC.13.6.914.

Dissociation between ion permeability and the lethal action of polyene antibiotics on Candida albicans

W C Chen, D L Chou, D S Feingold

Dissociation between ion permeability and the lethal action of polyene antibiotics on Candida albicans

W C Chen et al. Antimicrob Agents Chemother. 1978 Jun.

Abstract

Kinetic data on potassium release from and killing of Candida albicans by the four polyene antibiotics amphotericin B, amphotericin B methyl ester hydrochloride, nystatin, and nystatin methyl ester hydrochloride are presented. The nystatins were relatively more effective than the amphotericins in causing potassium release rather than killing. These data suggest that the aqueous channels or pores formed by the polyene antibiotics are not central to the lethal action of the drugs.

PubMed Disclaimer

References

    1. Biochem Biophys Res Commun. 1977 Jan 24;74(2):480-7 - PubMed
    1. Adv Lipid Res. 1976;14:127-70 - PubMed
    1. J Gen Microbiol. 1976 Sep;96(1):117-23 - PubMed
    1. J Gen Physiol. 1975 Apr;65(4):515-26 - PubMed
    1. Biochim Biophys Acta. 1976 Feb 19;426(1):17-30 - PubMed

Publication types

MeSH terms

LinkOut - more resources