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Comment
. 2022 Apr 26;119(17):e2204155119.
doi: 10.1073/pnas.2204155119. Epub 2022 Apr 22.

Time and tide of cerebellar synchrony

Chris I De Zeeuw  1   2 , Vincenzo Romano  1
Affiliations
Comment

Time and tide of cerebellar synchrony

Chris I De Zeeuw et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no competing interest.

Figures

Fig. 1.
Fig. 1.
Synchrony of CSs and SSs may be correlated with onset and offset of movements, respectively. (A) Schematic representation of the convergence of inhibitory Purkinje cells (P-cells) onto cerebellar nuclei neurons (CNNs). P-cells integrate the inputs received via the climbing fiber and mossy fiber–parallel fiber systems and compute an output that can be read out by the CNNs. When the converging P-cell output is synchronous, the downstream effects at the CNNs may be subject to training and/or elicit sequences of relative silence and subsequent rebound activity. CNNs either directly control behavior via premotor areas in the brainstem or they provide feedback to neurons in the inferior olive (IO), which are coupled by gap junctions and provide the climbing fibers to the P-cells. Granular cells (Gr-cells) receive input from the mossy fibers and give rise to the parallel fibers. (B) Raw traces of a voluntary whisker movement (black line, top) and two simultaneously recorded PC-cells (blue traces, bottom). The orange and blue dashed lines indicate the onset and offset of the movement, respectively, while orange and blue beams indicate periods during which both PC-cells show CSs and SSs, respectively. (C) Average whisker movements (top) and synchrony of CS activity (bottom) centered around movement onset (dashed orange line). (D) Average whisker movements (top) and synchrony of SS activity (bottom) centered around movement offset (dashed blue line). CS synchrony rises just before movement onset and SS synchrony occurs before the whisker movements cease. Note that the peak of SS synchrony coincides at a moment of deceleration (green arrow), similar to the main finding by Sedaghat-Nejad et al. in PNAS (17). Top and bottom black dashed lines demarcate two SDs higher or lower than the mean of the synchrony levels as observed during the resting epoch (−200 to −150 ms prior to movement onset). CS and SS data are from 106 P-cell pairs from Romano et al. (18, 19). Note that whisker movements in B, C, and D are presented as position signals. Shaded areas indicate the SEM.
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