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Editorial
. 2022 Jun 15;205(12):1377-1379.
doi: 10.1164/rccm.202203-0537ED.

Promises and Pitfalls of Multiomics Approaches to Pulmonary Arterial Hypertension

Catherine E Simpson  1 , Paul M Hassoun  1
Affiliations
Editorial

Promises and Pitfalls of Multiomics Approaches to Pulmonary Arterial Hypertension

Catherine E Simpson et al. Am J Respir Crit Care Med. .
No abstract available

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Comment on

  • Mining the Plasma Proteome for Insights into the Molecular Pathology of Pulmonary Arterial Hypertension.
    Harbaum L, Rhodes CJ, Wharton J, Lawrie A, Karnes JH, Desai AA, Nichols WC, Humbert M, Montani D, Girerd B, Sitbon O, Boehm M, Novoyatleva T, Schermuly RT, Ghofrani HA, Toshner M, Kiely DG, Howard LS, Swietlik EM, Gräf S, Pietzner M, Morrell NW, Wilkins MR; U.K. National Institute for Health Research BioResource Rare Diseases Consortium, U.K. Pulmonary Arterial Hypertension Cohort Study Consortium, and U.S. Pulmonary Arterial Hypertension Biobank Consortium. Harbaum L, et al. Am J Respir Crit Care Med. 2022 Jun 15;205(12):1449-1460. doi: 10.1164/rccm.202109-2106OC. Am J Respir Crit Care Med. 2022. PMID: 35394406 Free PMC article.

References

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    1. Rhodes CJ, Otero-Nunez P, Wharton J, Swietlik EM, Kariotis S, Harbaum L, et al. Whole-blood RNA profiles associated with pulmonary arterial hypertension and clinical outcome. Am J Respir Crit Care Med . 2020;202:586–594. - PMC - PubMed
    1. Hong J, Arneson D, Umar S, Ruffenach G, Cunningham CM, Ahn IS, et al. Single-cell study of two rat models of pulmonary arterial hypertension reveals connections to human pathobiology and drug repositioning. Am J Respir Crit Care Med . 2021;203:1006–1022. - PMC - PubMed
    1. Newman JH, Rich S, Abman SH, Alexander JH, Barnard J, Beck GJ, et al. Enhancing insights into pulmonary vascular disease through a precision medicine approach. A joint NHLBI-Cardiovascular Medical Research and Education Fund workshop report. Am J Respir Crit Care Med . 2017;195:1661–1670. - PMC - PubMed

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