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Comment
. 2022 Apr 21;82(8):1403-1404.
doi: 10.1016/j.molcel.2022.03.040.

There are more Hsp90 chaperone mechanisms in heaven and earth, dear reader, than are dreamt of in your philosophy

Eugenia M Clerico  1 , Lila M Gierasch  2
Affiliations
Comment

There are more Hsp90 chaperone mechanisms in heaven and earth, dear reader, than are dreamt of in your philosophy

Eugenia M Clerico et al. Mol Cell. .

Abstract

Dahiya et al. (2022) and Biebl et al. (2022) present mechanistic insights into the Hsp40/Hsp70/Hsp90 chaperone teamwork and the co-chaperones that participate in this network.

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Figures

Figure 1.
Figure 1.. A culinary metaphor for protein maturation by Hsp90
Hsp40 and Hsp70 team up as sous chefs to prepare clients (red, green, and blue) for hand off to the master chef Hsp90, which works with its team of co-chaperones to finalize the dishes
See this image and copyright information in PMC

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References

    1. Biebl MM, Delhommel F, Faust O, Zak KM, Agam G, Guo X, Mühlhofer M, Dahiya V, Hillebrand D, Popowicz GM, et al. (2022). NudC guides client transfer between the Hsp40/70 and Hsp90 chaperone systems. Mol. Cell 82, 555–569.e7. 10.1016/j.molcel.2021.12.031. - DOI - PubMed
    1. Biebl MM, Riedl M, and Buchner J (2020). Hsp90 co-chaperones form plastic genetic networks adapted to client maturation. Cell Rep 32, 108063–108080. 10.1016/j.celrep.2020.108063. - DOI - PubMed
    1. Dahiya V, Rutz DA, Moessmer P, Mühlhofer M, Lawatscheck J, Rief M, and Buchner J (2022). The switch from client holding to folding in the Hsp70/Hsp90 chaperone machineries is regulated by a direct interplay between co-chaperones. Mol. Cell 82, ■■■. - PubMed
    1. Genest O, Wickner S, and Doyle SM (2019). Hsp90 and Hsp70 chaperones: Collaborators in protein remodeling. J. Biol. Chem 294, 2109–2120. 10.1074/jbc.rev118.002806. - DOI - PMC - PubMed
    1. Kirschke E, Goswami D, Southworth D, Griffin PR, and Agard DA (2014). Glucocorticoid receptor function regulated by coordinated action of the Hsp90 and Hsp70 chaperone cycles. Cell 157, 1685–1697. 10.1016/j.cell.2014.04.038. - DOI - PMC - PubMed

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