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Comment
. 2022 Apr 21;82(8):1411-1413.
doi: 10.1016/j.molcel.2022.03.039.

DUB to the rescue

Wei Pin Teh  1 , He Zhu  2 , Jarrod A Marto  2 , Sara J Buhrlage  3
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Free article
Comment

DUB to the rescue

Wei Pin Teh et al. Mol Cell. .
Free article

Abstract

Henning et al. (2022) report development of a novel class of agents, bivalent deubiquitinase (DUB)-targeting chimeras (DUBTACs), that can selectively stabilize protein targets. These findings encourage further pursuit of targeted protein stabilization as a new paradigm in chemical biology and drug discovery.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • Deubiquitinase-targeting chimeras for targeted protein stabilization.
    Henning NJ, Boike L, Spradlin JN, Ward CC, Liu G, Zhang E, Belcher BP, Brittain SM, Hesse MJ, Dovala D, McGregor LM, Valdez Misiolek R, Plasschaert LW, Rowlands DJ, Wang F, Frank AO, Fuller D, Estes AR, Randal KL, Panidapu A, McKenna JM, Tallarico JA, Schirle M, Nomura DK. Henning NJ, et al. Nat Chem Biol. 2022 Apr;18(4):412-421. doi: 10.1038/s41589-022-00971-2. Epub 2022 Feb 24. Nat Chem Biol. 2022. PMID: 35210618 Free PMC article.

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