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. 2022 Apr 15;58(4):548.
doi: 10.3390/medicina58040548.

Brain Metastases from Gynecologic Malignancies

Georgia Karpathiou  1 , Florian Camy  1 , Céline Chauleur  2 , Maroa Dridi  1 , Pierre Dal Col  1 , Michel Peoc'h  1
Affiliations

Brain Metastases from Gynecologic Malignancies

Georgia Karpathiou et al. Medicina (Kaunas). .

Abstract

Background and Objectives: To present a series of brain metastases from gynecologic primaries and provide a summary of the relevant literature. Materials and Methods: We retrospectively review 18 patients with histologically confirmed brain metastases from gynecologic primaries and summarize the largest series of relative reports. Results: Six brain metastases were of endometrial primary and 12 of ovarian primary. In 3 cases (16.7%), diagnosis of brain metastases was made at presentation of the gynecologic primary; in the others, median time to development of brain metastasis was 34 (range, 6-115) months. Median survival after brain metastasis diagnosis was 5 (range, 1-89) months. Favorable prognostic factors were better performance status (p = 0.04) and, marginally, smaller metastasis size (p = 0.06). No differences in brain metastases between endometrial and ovarian primaries were found, except for the time interval from primary to brain metastases diagnosis, which was shorter for endometrial tumors (p = 0.05). A comprehensive summary of previous studies is provided. Conclusions: Performance status and smaller brain metastases size are good prognostic factors. Endometrial cancer brain metastases develop earlier than ovarian cancer brain metastases.

Keywords: brain metastasis; endometrial cancer; ovarian cancer.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
(A) Ovarian high grade serous carcinoma infiltrating cerebellar tissue (left). Papillary structures and necrosis seen at the right. (B) Grade 2 endometrioid adenocarcinoma infiltrating glial tissue (left). (C) Grade 3 endometrioid adenocarcinoma infiltrating glial tissue (right). (D) Overall survival (OS) according to performance status.
See this image and copyright information in PMC

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