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. 2022 Apr 17;58(4):553.
doi: 10.3390/medicina58040553.

Retrospective Comparison of Laparoscopic versus Open Radical Hysterectomy for Early-Stage Cervical Cancer in a Single Tertiary Care Institution from Lithuania between 2009 and 2019

Danuta Vasilevska  1 , Dominika Vasilevska  2 , Andrzej Semczuk  3 , Vilius Rudaitis  2
Affiliations

Retrospective Comparison of Laparoscopic versus Open Radical Hysterectomy for Early-Stage Cervical Cancer in a Single Tertiary Care Institution from Lithuania between 2009 and 2019

Danuta Vasilevska et al. Medicina (Kaunas). .

Abstract

Background and Objectives: A great debate within the academic arena was evoked by the LACC study, giving rise to doubt regarding the oncological outcomes of the laparoscopic approach for early-stage cervical cancer. This encouraged us to conduct a retrospective analysis of CC treatment surgical approaches applied to the patients at tertiary level Vilnius University Hospital Santaros Clinics, Vilnius, Lithuania, between 2009 and 2019. Materials and Methods: The retrospective study was carried out to evaluate the outcomes after 28 laparoscopic and 62 laparotomic radical hysterectomies for early cervical cancer in a single tertiary care institution performed during the period 2009-2019. For statistical analysis of patients' parameters, SPSS v. 17.0 was applied, together with the Kaplan-Meier method with a long-rank test and the Cox proportional hazard regression model used for bi-variate analysis determining OS outcomes between MIS and open-surgery groups. Results: After computing data with the Cox regression model, there was no significant difference of the 36-months overall survival between laparoscopy and laparotomy groups, as opposed to the LACC study. Conclusions: Our tertiary institution faces a considerable challenge, and we acknowledge the limitations of the study and also feel a responsibility to follow the latest guidelines. Currently, it appears that the most substantial attention should be focused on the cessation of uterine manipulator use as well as laparoscopic technique learning curves.

Keywords: LACC study; early-stage cervical cancer; radical hysterectomy; surgical gynecological oncology.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Kaplan–Meier 3-year OS curve of CC patients who underwent the laparoscopic or laparotomic surgical approach for RH.
Figure 2
Figure 2
Cox (proportional hazards) regression curves for 3-year OS between laparoscopic and laparotomic surgical approach for RH.
See this image and copyright information in PMC

References

    1. Zhang S.S., Ding T., Cui Z.H., Lv Y., Jiang R.A. Efficacy of robotic radical hysterectomy for cervical cancer compared with that of open and laparoscopic surgery: A separate meta-analysis of high-quality studies. Medicine. 2019;98:e14171. doi: 10.1097/MD.0000000000014171. - DOI - PMC - PubMed
    1. Kim S.I., Cho J.H., Seol A., Kim Y.I., Lee M., Kim H.S., Chung H.H., Kim J.W., Park N.H., Song Y.S. Comparison of survival outcomes between minimally invasive surgery and conventional open surgery for radical hysterectomy as primary treatment in patients with stage IB1-IIA2 cervical cancer. Gynecol. Oncol. 2019;153:3–12. doi: 10.1016/j.ygyno.2019.01.008. - DOI - PubMed
    1. Everatt R., Intaitė B. Trends in cervical cancer mortality rates in Lithuania, 1987–2016. Cancer Epidemiol. 2018;57:85–89. doi: 10.1016/j.canep.2018.10.008. - DOI - PubMed
    1. Kim J.H., Kim K., Park S.J., Lee J.Y., Kim K., Lim M.C., Kim J.W. Comparative Effectiveness of Abdominal versus Laparoscopic Radical Hysterectomy for Cervical Cancer in the Postdissemination Era. Cancer Res. Treat. 2019;51:788–796. doi: 10.4143/crt.2018.120. - DOI - PMC - PubMed
    1. Ramirez P.T., Frumovitz M., Pareja R., Lopez A., Vieira M., Ribeiro R., Buda A., Yan X., Shuzhong Y., Chetty N., et al. Minimally Invasive versus Abdominal Radical Hysterectomy for Cervical Cancer. N. Engl. J. Med. 2018;379:1895–1904. doi: 10.1056/NEJMoa1806395. - DOI - PubMed