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Editorial
. 2022 Apr 14;14(8):1983.
doi: 10.3390/cancers14081983.

The Importance of the Tumor Microenvironment to Understand Tumor Origin, Evolution, and Treatment Response

Jose M Ayuso  1   2   3 , Ignacio Ochoa Garrido  4   5   6
Affiliations
Editorial

The Importance of the Tumor Microenvironment to Understand Tumor Origin, Evolution, and Treatment Response

Jose M Ayuso et al. Cancers (Basel). .

Abstract

During the second half of the twentieth century, oncology adopted a tumor-centric approach to cancer treatment, focusing primarily on the tumor cell to identify new therapeutic targets [...].

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Conflict of interest statement

Ignacio Ochoa is promoter and consultant for BeOnChip S.L. and EBERS Medical Technology S.L. (Zaragoza, Spain). Both cited companies have had no role in the decision to publish nor were involved in the writing of this manuscript. Jose M. Ayuso declares no conflict of interest.

References

    1. Tchou J., Conejo-Garcia J. Targeting the tumor stroma as a novel treatment strategy for breast cancer: Shifting from the neoplastic cell-centric to a stroma-centric paradigm. Adv. Pharmacol. 2012;65:45–61. doi: 10.1016/B978-0-12-397927-8.00003-8. - DOI - PubMed
    1. Jin M.Z., Jin W.L. The updated landscape of tumor microenvironment and drug repurposing. Signal Transduct. Target. Ther. 2020;5:166. doi: 10.1038/s41392-020-00280-x. - DOI - PMC - PubMed
    1. Zhong S., Jeong J.H., Chen Z., Luo J.L. Targeting Tumor Microenvironment by Small-Molecule Inhibitors. Transl. Oncol. 2020;13:57–69. doi: 10.1016/j.tranon.2019.10.001. - DOI - PMC - PubMed
    1. Labani-Motlagh A., Ashja-Mahdavi M., Loskog A. The Tumor Microenvironment: A Milieu Hindering and Obstructing Antitumor Immune Responses. Front. Immunol. 2020;11:940. doi: 10.3389/fimmu.2020.00940. - DOI - PMC - PubMed
    1. Waldman A.D., Fritz J.M., Lenardo M.J. A guide to cancer immunotherapy: From T cell basic science to clinical practice. Nat. Rev. Immunol. 2020;20:651–668. doi: 10.1038/s41577-020-0306-5. - DOI - PMC - PubMed

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