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. 2022 Mar 25;10(4):511.
doi: 10.3390/vaccines10040511.

Postvaccination SARS-CoV-2 Infections among Healthcare Professionals: A Real World Evidence Study

Alessandro Perrella  1 , Sara Mucherino  2 , Ilaria Guarino  2 , Mariagiovanna Nerilli  1 , Alberto Enrico Maraolo  1 , Nicolina Capoluongo  1 , Enrico Coscioni  3   4 , Ugo Trama  3   5 , Enrica Menditto  2 , Valentina Orlando  2
Affiliations

Postvaccination SARS-CoV-2 Infections among Healthcare Professionals: A Real World Evidence Study

Alessandro Perrella et al. Vaccines (Basel). .

Abstract

Due to the COVID-19 pandemic, all countries with a global mobilization started to produce and authorize vaccines, prioritizing healthcare professionals (HCPs) to reduce transmission. The aim of this study was to assess post-vaccination infections' occurrence among HCPs and their correlation with symptom onset. A retrospective cohort study was carried out in the Campania Region from December 2020 to April 2021. Data were retrieved from the Regional Health Information System of the Campania Region (Sinfonia). The study cohort included subjects that had all received at least one vaccine dose. Risk ratios (RRs) adjusted for age and sex (95% confidence intervals) were performed to assess differences in the prevalence between HCPs who tested positive or negative for COVID-19. Univariate and multivariate logistic regression models were used to evaluate the association between symptoms and vaccination status. Findings revealed that HCPs had a lower risk of contracting COVID-19 after receiving at least one vaccine dose, and this risk decreased with age. Furthermore, not having full vaccination coverage may predict a severe/critical evolution of the disease. This study provides a snapshot of the initial state of the Italian vaccination campaign on HCPs. A surveillance approach using Big Data matched to clinical conditions could offer a real analysis in the categorization of subjects most at risk.

Keywords: COVID-19; COVID-19 symptoms; SARS-CoV-2; healthcare professionals; healthcare workers; vaccination.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flowchart.
Figure 2
Figure 2
Risk of testing positive after receiving at least one COVID-19 vaccine dose stratified by age.
See this image and copyright information in PMC

References

    1. Cucinotta D., Vanelli M. WHO Declares COVID-19 a Pandemic. Acta Biomed. 2020;91:157–160. doi: 10.23750/abm.v91i1.9397. - DOI - PMC - PubMed
    1. World Health Organization Coronavirus Disease (COVID-19) Pandemic. [(accessed on 1 July 2021)]. Available online: https://www.who.int/emergencies/diseases/novel-coronavirus-2019.
    1. Sharma O., Sultan A.A., Ding H., Triggle C.R. A Review of the Progress and Challenges of Developing a Vaccine for COVID-19. Front. Immunol. 2020;1:585354. doi: 10.3389/fimmu.2020.585354. - DOI - PMC - PubMed
    1. Awadasseid A., Wu Y., Tanaka Y., Zhang W. Current advances in the development of SARS-CoV-2 vaccines. Int. J. Biol. Sci. 2021;17:8–19. doi: 10.7150/ijbs.52569. - DOI - PMC - PubMed
    1. Hodgson S.H., Mansatta K., Mallett G., Harris V., Emary K.R.W., Pollard A.J. What defines an efficacious COVID-19 vaccine? A review of the challenges assessing the clinical efficacy of vaccines against SARS-CoV-2. Lancet Infect. Dis. 2021;21:e26–e35. doi: 10.1016/S1473-3099(20)30773-8. - DOI - PMC - PubMed

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