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Case Reports
. 2022 Apr 14;10(4):611.
doi: 10.3390/vaccines10040611.

COVID Vaccine-Associated Myocarditis in Adolescent Siblings: Does It Run in the Family?

Julia Moosmann  1 , Thomas Gentles  1   2 , Christopher Occleshaw  3 , Bryan Mitchelson  1
Affiliations
Case Reports

COVID Vaccine-Associated Myocarditis in Adolescent Siblings: Does It Run in the Family?

Julia Moosmann et al. Vaccines (Basel). .

Abstract

The development of myocarditis after receiving messenger RNA vaccination against COVID-19 is well documented, particularly in adolescent and young adult males. We report a case of vaccine-associated myocarditis in adolescent brothers following their second dose of the BNT162b2 mRNA vaccine (Pfizer-BioNTech, Mainz, Germany). This report illustrates the need to better understand the mechanisms leading to myocarditis after mRNA vaccination.

Keywords: COVID-19; children; myocarditis; vaccination.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Case 1 ECG findings. (A) ECG at presentation demonstrating abnormal repolarization, including T-wave inversion in V2–V3 and T-wave flattening in V4. (B) One month after presentation, showing resolution of these changes.
Figure 2
Figure 2
Cardiac MRI showing short-axis T2-weighted image with fat saturation. (A) Case 1: ill-defined area of increased signal in the inferior left ventricular myocardium indicative of focal oedema. (B) Case 2: more extensive region of oedema in comparison to case 1, which extends into the posterior obtuse marginal surface.
Figure 3
Figure 3
Comparison of trends in hs-Troponin T during the acute phase of myocarditis.
See this image and copyright information in PMC

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