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Review
. 2022 Mar 23;9(4):450.
doi: 10.3390/children9040450.

New Directions in Understanding Atopic March Starting from Atopic Dermatitis

Nunzia Maiello  1 , Pasquale Comberiati  2   3 , Arianna Giannetti  4 , Giampaolo Ricci  5 , Rossella Carello  6 , Elena Galli  6
Affiliations
Review

New Directions in Understanding Atopic March Starting from Atopic Dermatitis

Nunzia Maiello et al. Children (Basel). .

Abstract

Recent evidence showed that the postulated linear progression of the atopic march, from atopic dermatitis to food and respiratory allergies, does not capture the heterogeneity of allergic phenotypes, which are influenced by complex interactions between environmental, genetic, and psychosocial factors. Indeed, multiple atopic trajectories are possible in addition to the classic atopic march. Nevertheless, atopic dermatitis is often the first manifestation of an atopic march. Improved understanding of atopic dermatitis pathogenesis is warranted as this could represent a turning point in the prevention of atopic march. In this review, we outline the recent findings on the pathogenetic mechanisms leading to atopic dermatitis that could be targeted by intervention strategies for the prevention of atopic march.

Keywords: allergic rhinitis; asthma; atopic dermatitis; atopic march; eosinophilic esophagitis; food allergy.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Allergic march trajectories starting from atopic dermatitis. AD, atopic dermatitis; AR, allergic rhinitis; FA, food allergy.
See this image and copyright information in PMC

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