Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Apr 9;12(4):606.
doi: 10.3390/jpm12040606.

Collaborative Approach to Reach Everyone with Familial Hypercholesterolemia: CARE-FH Protocol

Laney K Jones  1   2 , Marc S Williams  2 , Ilene G Ladd  2 , Dylan Cawley  2 , Shuping Ge  3 , Jing Hao  4 , Dina Hassen  4 , Yirui Hu  4 , H Lester Kirchner  4 , Maria Kobylinski  5 , Michael G Lesko  1 , Matthew C Nelson  3 , Alanna K Rahm  2 , David D Rolston  6 , Katrina M Romagnoli  7 , Tyler J Schubert  2   8 , Timothy C Shuey  6 , Amy C Sturm  1   2 , Samuel S Gidding  2
Affiliations

Collaborative Approach to Reach Everyone with Familial Hypercholesterolemia: CARE-FH Protocol

Laney K Jones et al. J Pers Med. .

Abstract

The Collaborative Approach to Reach Everyone with Familial Hypercholesterolemia (CARE-FH) study aims to improve diagnostic evaluation rates for FH at Geisinger, an integrated health delivery system. This clinical trial relies upon implementation science to transition the initial evaluation for FH into primary care, attempting to identify individuals prior to the onset of atherosclerotic cardiovascular disease events. The protocol for the CARE-FH study of this paper is available online. The first phase of the project focuses on trial design, including the development of implementation strategies to deploy evidence-based guidelines. The second phase will study the intervention, rolled out regionally to internal medicine, community medicine, and pediatric care clinicians using a stepped-wedge design, and analyzing data on diagnostic evaluation rates, and implementation, service, and health outcomes.

Keywords: cholesterol screening; familial hypercholesterolemia; implementation science; prevention; primary care.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

Figures

Figure 1
Figure 1
Conceptual model of implementation research framework tailored to the CARE-FH protocol. JACC, Journal of the American College of Cardiology.
Figure 2
Figure 2
FH Diagnostic Evaluation Program. ASCVD, atherosclerosis cardiovascular disease; DLCN, Dutch Lipid Clinic Network score; FH, Familial hypercholesterolemia; Clinics will move from usual care to deployment of implementation strategy package during the stepped-wedge design.
See this image and copyright information in PMC

References

    1. Grundy S.M., Stone N.J., Bailey A.L., Beam C., Birtcher K.K., Blumenthal R.S., Braun L.T., de Ferranti S., Faiella-Tommasino J., Forman D.E., et al. 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J. Am. Coll. Cardiol. 2019;139:e1082–e1143. doi: 10.1016/j.jacc.2018.11.003. - DOI - PMC - PubMed
    1. NICE’s Guideline Updates Team . Familial Hypercholesterolaemia: Identification and Management: Evidence Reviews for Case-Finding, Diagnosis and Statin Monotherapy. National Institute for Health and Care Excellence; London, UK: 2017. - PubMed
    1. Watts G.F., Gidding S.S., Mata P., Pang J., Sullivan D.R., Yamashita S., Raal F.J., Santos R.D., Ray K.K. Familial hypercholesterolaemia: Evolving knowledge for designing adaptive models of care. Nat. Rev. Cardiol. 2020;17:360–377. doi: 10.1038/s41569-019-0325-8. - DOI - PubMed
    1. Goodman D.S., Hulley S.B., Clark L.T., Davis C.E., Fuster V., LaRosa J.C., Oberman A., Schaefer E.J., Steinberg D., Brown W.V., et al. Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. The Expert Panel. Arch. Intern. Med. 1988;148:36–69. doi: 10.1001/archinte.1988.00380010040006. - DOI - PubMed
    1. deGoma E.M., Ahmad Z.S., O’Brien E.C., Kindt I., Shrader P., Newman C.B., Pokharel Y., Baum S.J., Hemphill L.C., Hudgins L.C., et al. Treatment Gaps in Adults With Heterozygous Familial Hypercholesterolemia in the United States: Data from the CASCADE-FH Registry. Circ. Cardiovasc. Genet. 2016;9:240–249. doi: 10.1161/CIRCGENETICS.116.001381. - DOI - PMC - PubMed

LinkOut - more resources