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. 2022 Apr 11;11(8):2119.
doi: 10.3390/jcm11082119.

The Relationships between Abnormal Serum Lipid Levels, Depression, and Suicidal Ideation According to Sex

Kounseok Lee  1 , Sunhae Kim  1 , Jung Ki Jo  2
Affiliations

The Relationships between Abnormal Serum Lipid Levels, Depression, and Suicidal Ideation According to Sex

Kounseok Lee et al. J Clin Med. .

Abstract

(1) Background: Serum lipid levels affect not only nutritional status but also emotional state. The purpose of this study was to examine the effects of various socio-demographic characteristics, abnormal cholesterol levels, and BMI indicators on depressive symptoms and suicidal ideation in the Korean population. (2) Methods: A total of 23,692 people were surveyed using data from the Korea National Health and Nutrition Examination Survey (KNHNES) 2014, 2016, and 2018. Data from 11,653 patients were analyzed. Age, sex, chronic disease, smoking, alcohol consumption, total cholesterol (HDL, triglycerides), BMI, depression, and suicidal ideation were measured. (3) Results: According to sex, low HDL, high triglycerides, and suicidal ideation were significant, along with low education level, smoking, binge drinking, and high BMI. High triglyceride level was shown to significantly increase the risk of depression in males (OR = 1.535, 95% CI = 1.098-2.147). Factors affecting suicidal ideation in males were age, binge drinking, and depression, while blood lipid factors were not significant. (4) Conclusions: Of the types of serum lipid factors affecting depression and suicidal ideation, high triglycerides were found to be a risk factor for depression in men. Serum lipids can be used as biomarkers to reflect depressive symptoms in men depending on cholesterol level.

Keywords: cholesterol; depression; high-density lipoprotein; sex; suicidality; triglycerides.

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Conflict of interest statement

The authors declare no conflict of interest.

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