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. 2022 Apr 13;11(8):2173.
doi: 10.3390/jcm11082173.

Oncological Outcomes of Robotic Lobectomy and Radical Lymphadenectomy for Early-Stage Non-Small Cell Lung Cancer

Filippo Tommaso Gallina  1 , Riccardo Tajè  1 , Daniele Forcella  1 , Felicita Corzani  1 , Virna Cerasoli  1 , Paolo Visca  2 , Cecilia Coccia  3 , Federico Pierconti  3 , Isabella Sperduti  4 , Fabiana Letizia Cecere  5 , Federico Cappuzzo  6 , Enrico Melis  1 , Francesco Facciolo  1
Affiliations

Oncological Outcomes of Robotic Lobectomy and Radical Lymphadenectomy for Early-Stage Non-Small Cell Lung Cancer

Filippo Tommaso Gallina et al. J Clin Med. .

Abstract

Background: While the thoracotomy approach was considered the gold standard until two decades ago, robotic surgery has increasingly strengthened its role in lung cancer treatment, improving patients’ peri-operative outcomes. In this study, we report our experience in robotic lobectomy for early-stage non-small cell lung cancer, with particular attention to oncological outcomes and nodal upstaging rate. Methods: We retrospectively reviewed patients who underwent lobectomy and radical lymphadenectomy at our Institute between 2016 and 2020. We selected 299 patients who met the inclusion criteria of the study. We analyzed the demographic features of the groups as well as their nodal upstaging rate after pathological examination. Then, we analyzed disease-free and overall survival of the entire enrolled patient population and we compared the same oncological outcomes in the upstaging and the non-upstaging group. Results: A total of 299 patients who underwent robotic lobectomy were enrolled. After surgery, 55 patients reported nodal hilar or mediastinal upstaging. The 3-year overall survival of the entire population was 82.8%. The upstaging group and the non-upstaging group were homogeneous for age, gender, smoking habits, clinical stage, tumor site, tumor histology. The non-upstaging group had better OS (p = 0.004) and DFS (p < 0.0001). Conclusion: Our results show that robotic surgery is a safe and feasible approach for the treatment of early-stage NSCLC, especially for its accuracy in mediastinal lymphadenectomy. The oncological outcomes were encouraging and consistent with previous findings.

Keywords: early-stage NSCLC; lobectomy; nodal upstaging; robotic surgery.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Robotic ports placement.
Figure 2
Figure 2
(a) OS of the population; (b) OS of the population stratified for disease stage.
Figure 3
Figure 3
Comparison of the OS of the upstaging group with that of the non-upstaging group.
Figure 4
Figure 4
DFS of the population.
Figure 5
Figure 5
Comparison of the DFS of the upstaging group with that of the non-upstaging group.
See this image and copyright information in PMC

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References

    1. Siegel R.L., Miller K.D., Jemal A. Cancer statistics, 2015. CA Cancer J. Clin. 2015;65:5–29. doi: 10.3322/caac.21254. - DOI - PubMed
    1. Silvestri G.A., Gonzalez A.V., Jantz M.A., Margolis M.L., Gould M.K., Tanoue L.T., Harris L.J., Detterbeck F.C. Methods for Staging Non-small Cell Lung Cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest. 2013;143((Suppl. S5)):e211S–e250S. doi: 10.1378/chest.12-2355. - DOI - PubMed
    1. Swanson S.J., Herndon J.E., D’Amico T.A., Demmy T.L., McKenna R.J., Green M.R., Sugarbaker D.J. Video-Assisted Thoracic Surgery Lobectomy: Report of CALGB 39802—A Prospective, Multi-Institution Feasibility Study. J. Clin. Oncol. 2007;25:4993–4997. doi: 10.1200/JCO.2007.12.6649. - DOI - PubMed
    1. Zhang W., Wei Y., Jiang H., Xu J., Yu D. Thoracotomy is better than thoracoscopic lobectomy in the lymph node dissection of lung cancer: A systematic review and meta-analysis. World J. Surg. Oncol. 2016;14:290. doi: 10.1186/s12957-016-1038-7. - DOI - PMC - PubMed
    1. Nguyen D.M., Sarkaria I.S., Song C., Reddy R.M., Villamizar N., Herrera L.J., Shi L., Liu E., Rice D., Oh D.S. Clinical and economic comparative effectiveness of robotic-assisted, video-assisted thoracoscopic, and open lobectomy. J. Thorac. Dis. 2020;12:296–306. doi: 10.21037/jtd.2020.01.40. - DOI - PMC - PubMed

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