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. 2022 Apr 18;11(8):2266.
doi: 10.3390/jcm11082266.

Vertebral Osteomyelitis and Infective Endocarditis Co-Infection

Tadatsugu Morimoto  1 , Hirohito Hirata  1 , Koji Otani  2 , Eiichiro Nakamura  3 , Naohisa Miyakoshi  4 , Yoshinori Terashima  5 , Kanichiro Wada  6 , Takaomi Kobayashi  1 , Masatoshi Murayama  1 , Masatsugu Tsukamoto  1 , Masaaki Mawatari  1
Affiliations

Vertebral Osteomyelitis and Infective Endocarditis Co-Infection

Tadatsugu Morimoto et al. J Clin Med. .

Abstract

Many cases of vertebral osteomyelitis (VO) and infective endocarditis (IE) co-infection have been reported, and it has been recognized that attention should be paid to the possibility of both diseases co-existing during diagnosis and treatment. However, the incidence, clinical status, and outcomes of IE in patients with VO remain unclear. For this study, the eligibility criteria for patient recruitment included all cases of VO at the five medical university hospitals. Patients with a history of spinal surgery were excluded from this study. Echocardiography was routinely performed for all patients with VO. IE was diagnosed according to the modified Duke criteria for definite endocarditis. We analyzed demographic data, underlying conditions, clinical features, laboratory data, echocardiography, radiologic images, treatments, and outcomes. VO was diagnosed in 59 patients and IE was diagnosed in seven patients (12%). There were no significant differences in the clinical features, microorganisms, or radiographic status between the VO-IE co-infection and VO-only groups. In this study, using routine echocardiography for VO, the IE prevalence was 12%. The lack of specific clinical features and laboratory findings may hamper the diagnosis of IE. Therefore, clinicians are always required to suspect IE in patients with VO.

Keywords: co-infection; infective endocarditis; vertebral osteomyelitis.

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Akiyama T., Chikuda H., Yasunaga H., Horiguchi H., Fushimi K., Saita K. Incidence and risk factors for mortality of vertebral osteomyelitis: A retrospective analysis using the Japanese diagnosis procedure combination database. BMJ Open. 2013;3:e002412. doi: 10.1136/bmjopen-2012-002412. - DOI - PMC - PubMed
    1. Behmanesh B., Gessler F., Schnoes K., Dubinski D., Won S.Y., Konczalla J., Seifert V., Weise L., Setzer M. Infective endocarditis in patients with pyogenic spondylodiscitis: Implications for diagnosis and therapy. Neurosurg. Focus. 2019;46:E2. doi: 10.3171/2018.10.FOCUS18445. - DOI - PubMed
    1. Yamashita S., Tokushima M., Nakashima T., Katsuki N.E., Tago M., Yamashita S.I. Clinical Status Quo of Infective Endocarditis in a University Hospital in Japan: A Single-hospital-based Retrospective Cohort Study. Intern. Med. 2020;59:1497–1507. doi: 10.2169/internalmedicine.4159-19. - DOI - PMC - PubMed
    1. Yamashita S., Tago M., Tokushima M., Nakashima T., Katsuki N.E., Anzai K., Yamashita S.I. Status Quo of Diagnostic Procedures and Treatment of Inpatients with Infective Endocarditis at the Department of General Medicine at a University Hospital in a Suburban City in Japan: A Single-Hospital-Based Retrospective Study. Int. J. Gen. Med. 2020;13:547–557. doi: 10.2147/IJGM.S264497. - DOI - PMC - PubMed
    1. Habib G., Lancellotti P., Antunes M.J., Bongiorni M.G., Casalta J.P., Del Zotti F., Dulgheru R., El Khoury G., Erba P.A., Iung B., et al. 2015 ESC Guidelines for the management of infective endocarditis: The Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC). The European Association for Cardio-Thoracic Surgery (EACTS), European Association of Nuclear Medicine (EANM) Eur. Heart J. 2015;36:3075–3128. - PubMed

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