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Review
. 2022 Apr 8;14(8):1543.
doi: 10.3390/nu14081543.

Inositols, Probiotics, and Gestational Diabetes: Clinical and Epigenetic Aspects

Ester Vitacolonna  1   2 , Maria Masulli  3 , Luisa Palmisano  3 , Liborio Stuppia  2   4 , Marica Franzago  1   2
Affiliations
Review

Inositols, Probiotics, and Gestational Diabetes: Clinical and Epigenetic Aspects

Ester Vitacolonna et al. Nutrients. .

Abstract

There is growing interest in the potential role of different stereoisomers of inositol or their combination as well as probiotics supplementation in healthy glucose metabolism during pregnancy and in promoting offspring health. The aim of this review is to clarify the effects of several inositol and probiotics-based supplements in the prevention and treatment of gestational diabetes (GDM). Moreover, we will discuss the epigenetic aspects and their short- and long-term effects in response to probiotic intervention as well as the possible implications of these findings in guiding appropriate supplementation regimens in pregnancy.

Keywords: D-chiro inositol; Myo-inositol; epigenetic regulation; fetal programming; gestational diabetes; nutrition; probiotics.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The complex interactions among early nutrition, microbiome, epigenome and long-term health development.
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