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. 2022 Apr 11;14(8):1584.
doi: 10.3390/nu14081584.

Carica papaya Leaf Juice for Dengue: A Scoping Review

Bee Ping Teh  1   2 , Norzahirah Binti Ahmad  1 , Saharuddin Bin Mohamad  2   3 , Terence Yew Chin Tan  1 , Mohd Ridzuan Bin Mohd Abd Razak  1 , Adlin Binti Afzan  1 , Ami Fazlin Binti Syed Mohamed  1
Affiliations

Carica papaya Leaf Juice for Dengue: A Scoping Review

Bee Ping Teh et al. Nutrients. .

Abstract

The potential therapeutic effect of Carica papaya leaf juice has attracted wide interest from the public and scientists in relieving dengue related manifestations. Currently, there is a lack of evaluated evidence on its juice form. Therefore, this scoping review aims to critically appraise the available scientific evidence related to the efficacy of C. papaya leaf juice in dengue. A systematic search was performed using predetermined keywords on two electronic databases (PubMed and Google Scholar). Searched results were identified, screened and appraised to establish the association between C. papaya and alleviating dengue associated conditions. A total of 28 articles (ethnobotanical information: three, in vitro studies: three, ex vivo studies: one, in vivo study: 13, clinical studies: 10) were included for descriptive analysis, which covered study characteristics, juice preparation/formulations, study outcomes, and toxicity findings. Other than larvicidal activity, this review also reveals two medicinal potentials of C. papaya leaf juice on dengue infection, namely anti-thrombocytopenic and immunomodulatory effects. C. papaya leaf juice has the potential to be a new drug candidate against dengue disease safely and effectively.

Keywords: Carica papaya; dengue; flavonoid; juice; leaf; papaya; phenolic; platelet.

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Conflict of interest statement

No conflict of interest with regard to the review, authorship and publication of this manuscript. The funder had no role in the design of the review; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

Figures

Figure 1
Figure 1
Preferred reporting items for systematic review and meta-analysis (PRISMA) chart of articles searching and screening. Note: One included study conducted in vitro, ex vivo and in vivo experiments, which resulted in an additional three types of study.
See this image and copyright information in PMC

References

    1. Newman D.J., Cragg G.M. Natural products as sources of new drugs over the nearly four decades from 01/1981 to 09/2019. J. Nat. Prod. 2020;83:770–803. doi: 10.1021/acs.jnatprod.9b01285. - DOI - PubMed
    1. Zunjar V., Dash R., Jivrajani M., Trivedi B., Nivsarkar M. Antithrombocytopenic activity of carpaine and alkaloidal extract of Carica papaya Linn. leaves in busulfan induced thrombocytopenic Wistar rats. J. Ethnopharmacol. 2016;181:20–25. doi: 10.1016/j.jep.2016.01.035. - DOI - PubMed
    1. Julianti T., De Mieri M., Zimmermann S., Ebrahimi S.N., Kaiser M., Neuburger M., Raith M., Brun R., Hamburger M. HPLC-based activity profiling for antiplasmodial compounds in the traditional Indonesian medicinal plant Carica papaya L. J. Ethnopharmacol. 2014;155:426–434. doi: 10.1016/j.jep.2014.05.050. - DOI - PubMed
    1. Ogan A.U. The basic constituents of the leaves of Carica papaya. Phytochemistry. 1971;10:2544–2547. doi: 10.1016/S0031-9422(00)89908-2. - DOI
    1. Tang C.S. New macrocylic, ∆1-piperideine alkaloids from papaya leaves: Dehydrocarpaine I and II. Phytochemistry. 1979;18:651–652. doi: 10.1016/S0031-9422(00)84279-X. - DOI

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