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. 2022 Mar 31;14(4):732.
doi: 10.3390/v14040732.

PAGE-B and REACH-B Predicts the Risk of Developing Hepatocellular Carcinoma in Chronic Hepatitis B Patients from Northeast, Brazil

Alessandra Porto de Macedo Costa  1 , Marcos Antonio Custódio Neto da Silva  2 , Rogério Soares Castro  1 , Ana Leatrice de Oliveira Sampaio  1 , Antônio Machado Alencar Júnior  1 , Márcia Costa da Silva  3 , Adalgisa de Souza Paiva Ferreira  1
Affiliations

PAGE-B and REACH-B Predicts the Risk of Developing Hepatocellular Carcinoma in Chronic Hepatitis B Patients from Northeast, Brazil

Alessandra Porto de Macedo Costa et al. Viruses. .

Abstract

This study aims to evaluate the accuracy of the PAGE-B and REACH-B scores in predicting the risk of developing HCC in patients with chronic hepatitis B regularly followed up at a reference service in the State of Maranhão. A historical, longitudinal, retrospective cohort study, carried out from the review of medical records of patients with chronic Hepatitis B. PAGE-B and REACH-B scores were calculated and the accuracy of the scores in predicting the risk of HCC in the studied population was evaluated. A total of 978 patients were included, with a median age of around 47 years, most of them female and not cirrhotic. HCC was identified in 34 patients. Thrombocytopenia, high viral load, male gender and age were associated with the occurrence of HCC. The ROC curve for the PAGE-B score showed a value of 0.78 and for the REACH-B score of 0.79. The cutoff point for PAGE-B was 11 points for greater sensitivity and for REACH-B 7.5 points considering greater sensitivity and 9.5 points considering greater specificity. PAGE-B and REACH-B scores were able to predict the risk of developing HCC in the studied population. The use of risk stratification scores is useful to reduce costs associated with HCC screening.

Keywords: PAGE-B; REACH-B; chronic hepatitis B; hepatocellular carcinoma; prevalence; surveillance.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
ROC curve-dependent time for the PAGE-B variable.
Figure 2
Figure 2
ROC curve-dependent time for the REACH-B variable.
Figure 3
Figure 3
ROC curve for the PAGE-B variable.
Figure 4
Figure 4
ROC curve for the REACH-B variable.
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