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. 2022 Apr 12;27(8):2475.
doi: 10.3390/molecules27082475.

Metabolomic Markers for Predicting Preeclampsia in the First Trimester of Pregnancy: A Retrospective Study

Ekaterina V Ilgisonis  1 , Raisa Shalina  2 , Nigyar Kasum-Zade  2 , Kristina G Burkova  2 , Oxana P Trifonova  1 , Dmitry L Maslov  1 , Anna L Kaysheva  1 , Sergey S Markin  1
Affiliations

Metabolomic Markers for Predicting Preeclampsia in the First Trimester of Pregnancy: A Retrospective Study

Ekaterina V Ilgisonis et al. Molecules. .

Abstract

We sought to identify the characteristic metabolite profile of blood plasma samples obtained from patients with preeclampsia. Direct high-resolution mass spectrometry was used to analyze samples from 79 pregnant women, 34 of whom had preeclampsia. We performed a comparative analysis of the metabolite profiles and found that they differed between pregnant women with and without preeclampsia. Lipids and sugars were identified as components of the metabolite profile that are likely to be associated with the development of preeclampsia. While PE was established only in the third trimester, a set of metabolites specific for the third trimester, including 2-(acetylamino)-1,5-anhydro-2-deoxy-4-O-b-D-galactopyranosyl-D-arabino-Hex-1-enitol, N-Acetyl-D-glucosaminyldiphosphodolichol, Cer(d18:0/20:0), and allolithocholic acid, was already traced in the first trimester. These components are also likely involved in lipid metabolism disorders and the development of oxidative stress.

Keywords: digital medicine; direct mass spectrometry; metabolites; preeclampsia.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Frequencies (log scale) of nine m/z characteristics among four groups of patients without averaging over technical repetitions (TR). TR were considered as independent measurements. Group 1 and 2—a series of blood samples from patients in the control group and with developed PE, examined in the first trimester, respectively; Group 3 and 4—a series of blood samples from the study participants in the control group and with PE in the third trimester of pregnancy, respectively.
See this image and copyright information in PMC

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