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Comment
. 2022 Apr 22;7(1):127.
doi: 10.1038/s41392-022-00991-3.

Novel pyroptosis-independent functions of gasdermins

Ziran Qin  1 , Fangfang Zhou  2 , Long Zhang  3
Affiliations
Comment

Novel pyroptosis-independent functions of gasdermins

Ziran Qin et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Function of gasdermins in intestinal epithelial restitution and immune homeostasis. a In goblet cells, GSDMD pores mediate calcium ion influx, thereby activating scinderin-mediated F-actin disassembly and mucus secretion to form the mucus layer. GSDMD deficiency leads to the absence of the mucus layer and direct bacterial contact with the epithelium. b In epithelial cells, full-length GSDMB elevates intracellular PDGF-AA and thus promotes FAK phosphorylation, resulting in enhanced cell proliferation and migration. The carriage of GSDMB mutations leads to a defect in the repair capacity of epithelial cells
See this image and copyright information in PMC

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References

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