Cytogenetics or MRD in B-cell ALL. Do both reign supreme?

Yishai Ofran¹, Jacob M Rowe^{2

3

4}

Affiliations

¹ Department of Hematology and Bone Marrow Transplantation, Shaare Zedek Medical Center, Faculty of medicine, Hebrew University, Jerusalem, Israel.
² Department of Hematology and Bone Marrow Transplantation, Shaare Zedek Medical Center, Faculty of medicine, Hebrew University, Jerusalem, Israel. rowe@jimmy.harvard.edu.
³ Department of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus, Haifa, Israel. rowe@jimmy.harvard.edu.
⁴ Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel. rowe@jimmy.harvard.edu.

Editorial

Yishai Ofran et al. Leukemia. 2022 May.

. 2022 May;36(5):1201-1202.

doi: 10.1038/s41375-022-01575-4. Epub 2022 Apr 22.

Yishai Ofran¹, Jacob M Rowe^{2

3

4}

¹ Department of Hematology and Bone Marrow Transplantation, Shaare Zedek Medical Center, Faculty of medicine, Hebrew University, Jerusalem, Israel.
² Department of Hematology and Bone Marrow Transplantation, Shaare Zedek Medical Center, Faculty of medicine, Hebrew University, Jerusalem, Israel. rowe@jimmy.harvard.edu.
³ Department of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus, Haifa, Israel. rowe@jimmy.harvard.edu.
⁴ Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel. rowe@jimmy.harvard.edu.

No abstract available

References

1. Indgren V, Rowely J. Comparable complex rearrangements involving 8;21 and 9;22 translocations in leukaemia. Nature. 1977;266:744–5. - DOI
1. Moorman AV, Harrison CJ, Buck GAN, Richards SM, Secker-Walker LM, Martineau M, et al. on behalf of the Medical Research Council (MRC)/National Cancer Research Institute (NCRI) Adult Leukaemia Working Party of the United Kingdom and the Eastern Cooperative Oncology Group; Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII/Eastern Cooperative Oncology Group (ECOG) 2993 trial. Blood. 2007;109:3189–97. - DOI - PubMed
1. Moorman AV, Barretta E, Butler ER, Ward EJ, Twentyman K, Kirkwood AA, et al. Prognostic impact of chromosomal abnormalities and copy number alterations in adult B-cell precursor acute lymphoblastic leukaemia: a UKALL14 study. Leukemia. 2022;36:625–36.
1. Roberts KG, Li Y, Payne-Turner D, Harvey RC, Yang YL, Pei D, et al. Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia. N. Engl J Med. 2014;371:1005–15. https://doi.org/10.1056/NEJMoa1403088 . - DOI - PubMed - PMC
1. Paietta E, Roberts KG, Wang V, Gu Z, Buck GAN, Pei D, et al. Molecular classification improves risk assessment in adult BCR-ABL1-negative B-ALL. Blood. 2021;138:948–58. https://doi.org/10.1182/blood.2020010144 . - DOI - PubMed - PMC