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Review
. 2022 Jun:185:114303.
doi: 10.1016/j.addr.2022.114303. Epub 2022 Apr 21.

Drug delivery across the blood-brain barrier for the treatment of pediatric brain tumors - An update

Erica A Power  1 , Julian S Rechberger  1 , Sumit Gupta  2 , Jonathan D Schwartz  3 , David J Daniels  4 , Soumen Khatua  5
Affiliations
Review

Drug delivery across the blood-brain barrier for the treatment of pediatric brain tumors - An update

Erica A Power et al. Adv Drug Deliv Rev. 2022 Jun.

Abstract

Even though the last decade has seen a surge in the identification of molecular targets and targeted therapies in pediatric brain tumors, the blood brain barrier (BBB) remains a significant challenge in systemic drug delivery. This continues to undermine therapeutic efficacy. Recent efforts have identified several strategies that can facilitate enhanced drug delivery into pediatric brain tumors. These include invasive methods such as intra-arterial, intrathecal, and convection enhanced delivery and non-invasive technologies that allow for transient access across the BBB, including focused ultrasound and nanotechnology. This review discusses current strategies that are being used to enhance delivery of different therapies across the BBB to the tumor site - a major unmet need in pediatric neuro-oncology.

Keywords: Blood Brain Barrier; Drug Delivery; Pediatric Brain Tumors.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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