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. 2022 Oct;36(10):1745-1750.
doi: 10.1111/jdv.18174. Epub 2022 May 7.

Diet quality is associated with primary melanoma thickness

M C B Hughes  1 , M Malt  1 , K Khosrotehrani  2   3 , B M Smithers  4 , A C Green  1   5
Affiliations

Diet quality is associated with primary melanoma thickness

M C B Hughes et al. J Eur Acad Dermatol Venereol. 2022 Oct.

Abstract

Background: Patients' diets can influence the outcome of several common cancers, but the effect on melanoma prognosis is unknown.

Objective: To assess the association between quality of melanoma patients' prediagnosis diets and primary tumour thickness, the main prognostic indicator for melanoma.

Methods: We used baseline data from patients newly diagnosed with tumour stage Ib to IV cutaneous melanoma, with completed questionnaires about food intake in the past year and other factors. Diet quality was measured by the Healthy Eating Index (HEI) and melanoma thickness was extracted from histopathology reports. We estimated prevalence ratios (PRadj ) and 95% confidence intervals (CIs) adjusted for confounding factors using Poisson regression models to assess associations between HEI scores and melanoma thickness.

Results: Of 634 study patients, 238 (38%) had melanomas >2 mm thick at diagnosis. Patients with the highest HEI scores were significantly less likely to be diagnosed with thick melanoma than patients with lowest HEI scores (PRadj 0.93, 95% CI 0.86-0.99) (Ptrend = 0.03). There was no evidence of effect modification by age, sex, previous melanoma or comorbidities.

Conclusions: Melanoma thickness at diagnosis is significantly associated with quality of patients' diets before diagnosis.

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References

    1. Hurtado‐Barroso S, Trius‐Soler M, Lamuela‐Raventos RM et al. Vegetable and fruit consumption and prognosis among cancer survivors: a systematic review and meta‐analysis of cohort studies. Adv Nutr 2020; 11: 1569–1582. - PMC - PubMed
    1. Kohler LN, Garcia DO, Harris RB et al. Adherence to diet and physical activity cancer prevention guidelines and cancer outcomes: a systematic review. Cancer Epidemiol Biomarkers Prev 2016; 25: 1018–1028. - PMC - PubMed
    1. Nagle CM, Wilson LF, Hughes MC et al. Cancers in Australia in 2010 attributable to the consumption of red and processed meat. Aust N Z J Public Health 2015; 39: 429–433. - PMC - PubMed
    1. Nagle CM, Wilson LF, Hughes MC et al. Cancers in Australia in 2010 attributable to inadequate consumption of fruit, non‐starchy vegetables and dietary fibre. Aust N Z J Public Health 2015; 39: 422–428. - PMC - PubMed
    1. Davies NJ, Batehup L, Thomas R. The role of diet and physical activity in breast, colorectal, and prostate cancer survivorship: a review of the literature. Br J Cancer 2011; 105(Suppl 1): S52–S73. - PMC - PubMed