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Review
. 2022 Mar;13(1):143-151.
doi: 10.1007/s13193-021-01319-3. Epub 2021 Apr 27.

Management of Primary Hyperparathyroidism

Murad Lala  1
Affiliations
Review

Management of Primary Hyperparathyroidism

Murad Lala. Indian J Surg Oncol. 2022 Mar.

Abstract

Primary hyperparathyroidism (PHPT) is the unregulated overproduction of parathyroid hormone (PTH) resulting in abnormal calcium homeostasis. The disease profile has evolved over the last century from symptomatic hyperparathyroidism to asymptomatic hyperparathyroidism. Primary hyperparathyroidism is a biochemical diagnosis. Parathyroidectomy is the only established cure for this disease. Every effort is made to localize the offending gland preoperaively with various imaging modalities. These localization studies along with intraoperative parathormone monitoring will direct the surgeon to either a focused parathyroidectomy or a four gland exploration. All symptomatic patients and asymptomatic patients who meet the criteria for surgery should undergo parathyroidectomy if no medical contraindications exist. Pharmacologic approaches are reserved for those patients unfit or unwilling to undergo surgery.

Keywords: Diagnosis; Epidemiology; Hyperparathyroidism; Medical management; Parathyroidectomy; Preoperative imaging; Primary.

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Conflict of interest statement

Conflict of InterestThe author declares no competing interests.

Figures

Fig. 1
Fig. 1
Target organ systems affected in hyperparathyroidism
See this image and copyright information in PMC

References

    1. Tezelman S, Shen W, Shaver JK, et al. Double parathyroid adenomas. Clinical and biochemical characteristics before and after parathyroidectomy. Ann Surg. 1993;218(3):300–309. doi: 10.1097/00000658-199309000-00009. - DOI - PMC - PubMed
    1. Bilezikian JP, Silverberg SJ, Clinical practice Asymptomatic primary hyperparathyroidism. N Engl J Med. 2004;350(17):1746–1751. doi: 10.1056/NEJMcp032200. - DOI - PubMed
    1. Griebeler ML, Kearns AE, Ryu E, Hathcock MA, Melton LJ, 3rd, Wermers RA. Secular trends in the incidence of primary hyperparathyroidism over five decades (1965-2010) Bone. 2015;73:1–7. doi: 10.1016/j.bone.2014.12.003. - DOI - PMC - PubMed
    1. Yeh MW, Ituarte PH, Zhou HC, et al. Incidence and prevalence of primary hyperparathyroidism in a racially mixed population. J Clin Endocrinol Metab. 2013;98(3):1122–1129. doi: 10.1210/jc.2012-4022. - DOI - PMC - PubMed
    1. Raue F, Jacubeit T, Minne H, Herfarth C, Ziegler R. Primärer Hyperparathyreoidismus--Anderung eines Krankheitsbildes [Primary hyperparathyroidism--changes in the disease picture] Med Klin (Munich) 1989;84(4):178–182. - PubMed

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