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Review
. 2022 Apr 6:13:849513.
doi: 10.3389/fphar.2022.849513. eCollection 2022.

The Role of Flavonoids in the Osteogenic Differentiation of Mesenchymal Stem Cells

Jinli Zhang  1 , Zhihe Liu  1 , Yang Luo  2 , Xiaojian Li  3 , Guowei Huang  1 , Huan Chen  1 , Aiguo Li  1 , Shengnan Qin  1
Affiliations
Review

The Role of Flavonoids in the Osteogenic Differentiation of Mesenchymal Stem Cells

Jinli Zhang et al. Front Pharmacol. .

Abstract

Mesenchymal stem cells (MSCs) play an important role in developing bone tissue engineered constructs due to their osteogenic and chondrogenic differentiation potential. MSC-based tissue engineered constructs are generally considered a safe procedure, however, the long-term results obtained up to now are far from satisfactory. The main causes of these therapeutic limitations are inefficient homing, engraftment, and directional differentiation. Flavonoids are a secondary metabolite, widely existed in nature and have many biological activities. For a long time, researchers have confirmed the anti-osteoporosis effect of flavonoids through in vitro cell experiments, animal studies. In recent years the regulatory effects of flavonoids on mesenchymal stem cells (MSCs) differentiation have been received increasingly attention. Recent studies revealed flavonoids possess the ability to modulate self-renewal and differentiation potential of MSCs. In order to facilitate further research on MSCs osteogenic differentiation of flavonoids, we surveyed the literature published on the use of flavonoids in osteogenic differentiation of MSCs, and summarized their pharmacological activities as well as the underlying mechanisms, aimed to explore their promising therapeutic application in bone disorders and bone tissue engineered constructs.

Keywords: flavonoids; mesenchymal stem cells; osteogenic differentiation; osteoporosis; tissue engineering.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Schematic presentation of the biological activity of flavonoids.
FIGURE 2
FIGURE 2
Signalling pathways of flavonoids in MSCs osteogenic differentiation.
See this image and copyright information in PMC

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