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Review
. 2022 Apr 7:13:875103.
doi: 10.3389/fphar.2022.875103. eCollection 2022.

Mechanism Underlying Acupuncture Therapy in Spinal Cord Injury: A Narrative Overview of Preclinical Studies

Kunpeng Jiang  1 , Yulin Sun  2 , Xinle Chen  2
Affiliations
Review

Mechanism Underlying Acupuncture Therapy in Spinal Cord Injury: A Narrative Overview of Preclinical Studies

Kunpeng Jiang et al. Front Pharmacol. .

Erratum in

Abstract

Spinal cord injury (SCI) results from various pathogenic factors that destroy the normal structure and function of the spinal cord, subsequently causing sensory, motor, and autonomic nerve dysfunction. SCI is one of the most common causes of disability and death globally. It leads to severe physical and mental injury to patients and causes a substantial economic burden on families and the society. The pathological changes and underlying mechanisms within SCI involve oxidative stress, apoptosis, inflammation, etc. As a traditional therapy, acupuncture has a positive effect promoting the recovery of SCI. Acupuncture-induced neuroprotection includes several mechanisms such as reducing oxidative stress, inhibiting the inflammatory response and neuronal apoptosis, alleviating glial scar formation, promoting neural stem cell differentiation, and improving microcirculation within the injured area. Therefore, the recent studies exploring the mechanism of acupuncture therapy in SCI will help provide a theoretical basis for applying acupuncture and seeking a better treatment target and acupuncture approach for SCI patients.

Keywords: acupuncture; apoptosis; inflammation; mechanism; neuroprotection; oxidative stress; spinal cord injury; therapy.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Illustration of the possible mechanism underlying acupuncture therapy in SCI, including oxidative stress reduction, inflammation and apoptosis inhibition, microcirculation improvement, reduction of glial scar formation, and stimulation of NSC differentiation and proliferation.
See this image and copyright information in PMC

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