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. 2022 Apr;37(2):212-217.
doi: 10.1007/s12291-021-00976-z. Epub 2021 Apr 20.

To Study the Role of Serum Homocysteine Levels and Ocular Involvement in Retinal Vasculitis

Angad Miskin  1 , Raji Kurumkattil  1 , Anurodh Gupta  2 , Hemant Singh Trehan  1 , Puja Dudeja  3 , Sanjay Kumar Dhar  1 , Vijay Kumar Sharma  1
Affiliations

To Study the Role of Serum Homocysteine Levels and Ocular Involvement in Retinal Vasculitis

Angad Miskin et al. Indian J Clin Biochem. 2022 Apr.

Abstract

Idiopathic retinal vasculitis is a chronic disease of unknown aetiology which results in ocular morbidity in patients of productive age group. Homocysteine has been implicated in various ocular conditions like age-related macular degeneration, retinal vein occlusions, diabetic retinopathy, and optic nerve diseases. We conducted a study to investigate the relation between serum homocysteine levels and retinal vasculitis at a tertiary care centre in North India. In this case-control study, 32 cases and 64 controls were included and the duration was from June 2017 to March 2019. Serum homocysteine of cases and controls was detected by reflectance photometry using VITROS Chemistry Products HCY 2 (Homocysteine) and the normal range of serum homocysteine as per this method was 6.60 to 14.80 micro mol per litre. Our study found that of the total 32 retinal vasculitis patients, serum homocysteine was raised in 65.62% (21 cases out of 32) and in 70.31% of control group (45 out of 64). Chi square test results showed that there was no significant association found between S. homocysteine levels and Reticular vasculitis (P: 0.64). The two groups were comparable in terms of the age with mean ± SD in cases being 33.47 ± 8.336 years and controls being 35.16 ± 8.568 years with a P value of 0.37 being statistically insignificant. The data collected was analysed using SSPS-16 (Statistical Package for Social Sciences Version 16) software and test of association was Odd's ratio. Power of study was 80% and P < 0.05 is considered statistically significant. We found that there is no significant association between raised serum homocysteine and retinal vasculitis (with P < 0.64). Odds ratio was 0.80(0.33-1.99) implying that the cases and controls were statistically significantly different with respect to homocysteine levels.

Keywords: Homocysteine levels; Ocular involvement; Retinal vasculitis.

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Conflict of interest statement

Conflict of interestNone.

Figures

Fig. 1
Fig. 1
Retinal vasculitis with retinal haemorrhages, sheathing along vessels and hard exudates
Fig. 2
Fig. 2
Best corrected visual acuity distribution among cases and controls
Fig. 3
Fig. 3
Distribution of serum homocysteine among cases and controls
See this image and copyright information in PMC

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