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Review
. 2022 Apr 7:12:857743.
doi: 10.3389/fonc.2022.857743. eCollection 2022.

miR-1908 Dysregulation in Human Cancers

Jinze Shen  1 , Yuchen Wu  2 , Wenjing Ruan  3 , Feng Zhu  1 , Shiwei Duan  1
Affiliations
Review

miR-1908 Dysregulation in Human Cancers

Jinze Shen et al. Front Oncol. .

Abstract

MiR-1908 is a miRNA located in the intron of the fatty acid desaturase 1 (FADS1) gene. The expression level of miR-1908 is abnormal in many diseases such as cancer. miR-1908 can inhibit the expression of at least 27 target genes by binding to the 3' untranslated region (3' UTR) of target genes. miR-1908 is involved in the biological processes of cell proliferation, cell differentiation, cell apoptosis, cancer cell invasion, and metastasis. The expression of miR-1908 is regulated by 11 factors, including lncRNA HOTTIP, adipokines (TNF-α, leptin, and resistin), NF-κB, free fatty acid (FFA), cholesterol, stearoyl-CoA desaturase (SCD1), immune-related transcription factors (STAT1, RB1, and IRF1). The expression of miR-1908 is also affected by the anticancer drug OSW-1, growth hormone (GH), and the anticonvulsant drug sodium valproate. In addition, the aberrant expression of miR-1908 is also related to the prognosis of a variety of cancers, including non-small cell lung cancer (NSCLC), ovarian cancer (OC), breast cancer, cervical cancer, glioma, high-grade serous ovarian carcinoma (HGSOC), osteosarcoma, etc. This article summarizes the abnormal expression pattern of miR-1908 in various diseases and its molecular regulation mechanisms. Our work will provide potential hints and direction for future miR-1908-related research.

Keywords: cancer; ceRNA; diagnosis; miR-1908; prognosis.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The targeted genes of miR-1908-5p and their effects on cell behaviors. miR-1908-5p regulates cell apoptosis, proliferation, invasion, differentiation, secretion of exosomes by targeting 16 genes.
Figure 2
Figure 2
miR-1908-5p is involved in the regulation of multiple signaling pathways. miR-1908-5p plays an important role in the MAPK signaling pathway and PI3k/Akt signaling pathway. The positive feedback loop of NF-κB/miR-1908-5p/NKIRAS2/NF-κB enhances the promoting effect of the SRSF3/TAK1/NF-κB axis on the expression of miR-1908-5p.
Figure 3
Figure 3
miR-1908-5p plays a role in melanoma and Alzheimer’s disease by targeting ApoE.
Figure 4
Figure 4
Molecular regulatory mechanisms of miR-1908-5p in cancer. NSCLC, non-small cell lung cancer; PCa, prostate cancer; miR-1908-5p plays an important role in various cancers by regulating downstream gene expression.
Figure 5
Figure 5
miR-1908-5p regulates LDL-C metabolism in blood through the TGF-β1 signaling pathway. TGFR1, TGF receptor 1; TGFR2, TGF receptor 2; LDL-C, low-density lipoprotein cholesterol; FL-LDLR, full-length LDL receptor; C-LDLR, cleaved LDL receptor. miR-1908-5p plays an pivotal role in the process of organ and tissue fibrosis and atherosclerosis by targeting TGF-β1.
Figure 6
Figure 6
The regulation of miR-1908-5p in lipid metabolism. SAT, subcutaneous adipose tissue; VAT, visceral adipose tissue; LDL-C, low-density lipoprotein cholesterol; The differential expression of miR-1908-5p in different organs may be related to the distribution of adipose tissue, and its abnormal expression may be related to fatty liver and atherosclerosis.
Figure 7
Figure 7
Molecular mechanisms of potential drugs that can modulate miR-1908-5p. HCC, hepatocellular carcinoma; BD, bipolar disorder.
See this image and copyright information in PMC

References

    1. Chen Y, Li T, Gao Q, Wang LY, Cui LQ. MiR-1908 Improves Cardiac Fibrosis After Myocardial Infarction by Targeting TGF-Beta1. Eur Rev Med Pharmacol Sci (2018) 22(7):2061–9. doi: 10.26355/eurrev_201804_14736 - DOI - PubMed
    1. Zhou C, Zhao X, Duan S. The Role of miR-543 in Human Cancerous and Noncancerous Diseases. J Cell Physiol (2021) 236(1):15–26. doi: 10.1002/jcp.29860 - DOI - PubMed
    1. Li H, Li Y, Tian D, Zhang J, Duan S. miR-940 Is a New Biomarker With Tumor Diagnostic and Prognostic Value. Mol Ther Nucleic Acids (2021) 25:53–66. doi: 10.1016/j.omtn.2021.05.003 - DOI - PMC - PubMed
    1. Kuang Q, Li J, You L, Shi C, Ji C, Guo X, et al. Identification and Characterization of NF-kappaB Binding Sites in Human miR-1908 Promoter. BioMed Pharmacother (2015) 74:158–63. doi: 10.1016/j.biopha.2015.08.018 - DOI - PubMed
    1. Bar M, Wyman SK, Fritz BR, Qi J, Garg KS, Parkin RK, et al. MicroRNA Discovery and Profiling in Human Embryonic Stem Cells by Deep Sequencing of Small RNA Libraries. Stem Cells (2008) 26(10):2496–505. doi: 10.1634/stemcells.2008-0356 - DOI - PMC - PubMed