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. 2022 Apr;78(2):157-163.
doi: 10.1016/j.mjafi.2020.08.002. Epub 2020 Oct 24.

Evaluation of the effects of 0.05% sodium hypochlorite and 0.12% chlorhexidine gluconate twice daily rinse on periodontal parameters and gingival crevicular fluid HSV1 and CMV levels in patients with chronic periodontitis: a multicentric study

Sangeeta Singh  1 , Parul Sharma  2 , Mahadevan Kumar  3
Affiliations

Evaluation of the effects of 0.05% sodium hypochlorite and 0.12% chlorhexidine gluconate twice daily rinse on periodontal parameters and gingival crevicular fluid HSV1 and CMV levels in patients with chronic periodontitis: a multicentric study

Sangeeta Singh et al. Med J Armed Forces India. 2022 Apr.

Abstract

Background: Mechanical debridement of periodontal pockets remains the mainstay of therapy in all forms of periodontitis. There is 47% greater reduction in plaque amount when sodium hypochlorite (NaOCl) is used as an adjunct when compared with water rinsing. The aim of this study was to evaluate the effects of 0.05% NaOCl and 0.12% chlorhexidine gluconate twice daily rinse on periodontal parameters and gingival crevicular fluid (GCF) HSV1 and CMV levels in chronic periodontitis.

Methods: Patients assigned to group A were prescribed 0.05% NaOCl mouthwash for twice daily rinse. Patients in group B were prescribed 0.12% chlorhexidine gluconate mouthwash to be used twice daily. Evaluation of periodontal parameters was done at baseline and after six months following therapy. GCF HSV1 and CMV levels were evaluated using a polymerase chain reaction.

Results: A statistically significant difference was noted in the improvement in periodontal parameters between both groups, when evaluated six months following therapy with greater reduction in group A vis-a-vis group B.

Conclusion: NaOCl when prescribed as a twice daily mouthwash can be recommended as a part of the home care regime in patients with chronic periodontitis. It is more cost-effective, easily available and can be beneficial to the troops in difficult terrains and extremes of climates, where oral healthcare facilities are not easily accessible.

Keywords: Chlorhexidine gluconate; Cytomegalovirus; Gingival crevicular fluid (GCF); Herpes simplex virus-1 (HSV-1); Periodontitis; Sodium hypochlorite.

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Conflict of interest statement

The authors have none to declare.

Figures

Fig. 1
Fig. 1
Gingival crevicular fluid (GCF) samples collected and stored.
Fig. 2
Fig. 2
HSV kit and CMV kit.
Fig. 3
Fig. 3
PCR set-up.
Fig. 4
Fig. 4
Real-time PCR.
See this image and copyright information in PMC

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