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Review
. 2022 Apr;78(2):131-135.
doi: 10.1016/j.mjafi.2022.03.004. Epub 2022 Mar 23.

Resurgence of syphilis, the great imitator

Durga M Tripathy  1 , Somesh Gupta  2 , Biju Vasudevan  3
Affiliations
Review

Resurgence of syphilis, the great imitator

Durga M Tripathy et al. Med J Armed Forces India. 2022 Apr.

Abstract

Syphilis, one of the earliest diseases to be discovered in humans, still remains an enigma when it comes to its myriad manifestations and changing epidemiological profiles. There has been a surge in cases in the last few decades due to various factors. The human immunodeficiency virus (HIV) epidemics, global travel, increased incidence of male to male sexually transmitted diseases, online relationships culminating in casual sex are few of the important factors. Increased awareness could also be a factor for increased diagnosis. The multitude of clinical features especially when it comes to secondary syphilis and the rare tertiary manifestations, which can mimic various systemic disorders still pose a diagnostic challenge to the best of venereologists and physicians. This review aims to discuss the causes of resurgence in syphilis and few recent developments in pathogenesis, which could have led to this resurgence.

Keywords: Great imitator; Human immunodeficiency virus; Resurgence; Syphilis; Transmission.

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Conflict of interest statement

The authors have none to declare.

References

    1. Bach S., Heavey E. Resurgence of syphilis in the US. Nurse Pract. 2021;46(10):28–35. - PubMed
    1. Spiteri G., Unemo M., Mårdh O., Amato-Gauci A.J. The resurgence of syphilis in high-income countries in the 2000s: a focus on Europe. Epidemiol Infect. 2019;147:e143. - PMC - PubMed
    1. Schmidt R., Carson P.J., Jansen R.J. Resurgence of syphilis in the United States: an assessment of contributing factors. Infect Dis (Auckl) 2019;12 1178633719883282. - PMC - PubMed
    1. Willeford W.G., Bachmann L.H. Syphilis ascendant: a brief history and modern trends. Trop Dis Travel Med Vaccines. 2016;26:20. - PMC - PubMed
    1. Rohatgi S., Jindal S., Viradiya H.M. Syphilis incognito: resurgence of the covert devil. Indian J Sex Transm Dis AIDS. 2016;37(1):90–91. - PMC - PubMed

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