The Relationship Between Cord Blood Cytokine Levels and Perinatal Characteristics and Bronchopulmonary Dysplasia: A Case-Control Study

doi:10.3389/fped.2022.807932

. 2022 Apr 7:10:807932.

doi: 10.3389/fped.2022.807932. eCollection 2022.

The Relationship Between Cord Blood Cytokine Levels and Perinatal Characteristics and Bronchopulmonary Dysplasia: A Case-Control Study

Mengmeng Wang^{1

2

3}, Chenghan Luo⁴, Zanyang Shi^{1

2

3}, Xinru Cheng^{1

2

3}, Mengyuan Lei⁵, Wenjun Cao^{1

2

3}, Jingdi Zhang^{1

2

3}, Jian Ge^{1

2

3}, Min Song^{1

2

3}, Wenqian Ding^{1

2

3}, Yixia Zhang^{1

2

3}, Min Zhao⁶, Qian Zhang^{1

2

3}

Affiliations

¹ Neonatal Intensive Care Unit, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
² Clinical Treatment and Follow-Up Center for High-Risk Newborns of Henan Province, Zhengzhou, China.
³ Key Laboratory for Prevention and Control of Developmental Disorders, Zhengzhou, China.
⁴ Department of Orthopaedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
⁵ Health Care Department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
⁶ Medical Record Management Section, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

PMID: 35463904
PMCID: PMC9021742
DOI: 10.3389/fped.2022.807932

The Relationship Between Cord Blood Cytokine Levels and Perinatal Characteristics and Bronchopulmonary Dysplasia: A Case-Control Study

Mengmeng Wang et al. Front Pediatr. 2022.

. 2022 Apr 7:10:807932.

doi: 10.3389/fped.2022.807932. eCollection 2022.

Authors

Affiliations

¹ Neonatal Intensive Care Unit, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
² Clinical Treatment and Follow-Up Center for High-Risk Newborns of Henan Province, Zhengzhou, China.
³ Key Laboratory for Prevention and Control of Developmental Disorders, Zhengzhou, China.
⁴ Department of Orthopaedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
⁵ Health Care Department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
⁶ Medical Record Management Section, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

PMID: 35463904
PMCID: PMC9021742
DOI: 10.3389/fped.2022.807932

Abstract

Objective: To establish the association between serial levels of inflammatory cytokines in cord blood and perinatal characteristics and bronchopulmonary dysplasia (BPD) in preterm infants.

Methods: 147 premature infants with gestational age ≤32 weeks who were born and hospitalized in the First Affiliated Hospital of Zhengzhou University between July 2019 and August 2021 were enrolled in this retrospective case-control study. Multiple microsphere flow immunofluorescence was used to detect seven cytokines in cord blood collected within 24 h of birth. Demographics, delivery characteristics, maternal factors, neonatal characteristics, and clinical outcomes were collected for the two groups. An unconditional logistic regression model was used in this study to assess the clinical variables.

Results: IL-6 cord blood levels at birth were significantly higher in the BPD group than in the non-BPD group, but the odds ratio (OR) was very small (OR = 1). No differences in other cytokine concentrations were observed between the two groups. Multivariable logistic regression analysis demonstrated that increased maternal white blood cell (WBC) count on admission and lower birth weight increased the risk of BPD progression.

Conclusions: Increased IL-6 cord blood levels at birth in preterm infants may have trivial significance for predicting BPD. Furthermore, higher maternal WBC count on admission and lower birth weight increased the risk of BPD.

Keywords: bronchopulmonary dysplasia; cord blood; cytokines; maternal; perinatal factors.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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References

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[1] Northway WH, Jr., Rosan RC, Porter DY. Pulmonary disease following respirator therapy of hyaline-membrane disease Bronchopulmonary dysplasia. N Engl J Med. (1967) 276:357–68. 10.1056/NEJM196702162760701 - DOI - PubMed

[2] Northway WH, Jr., Rosan RC, Porter DY. Pulmonary disease following respirator therapy of hyaline-membrane disease Bronchopulmonary dysplasia. N Engl J Med. (1967) 276:357–68. 10.1056/NEJM196702162760701 - DOI - PubMed

[3] Thébaud B, Goss KN, Laughon M, Whitsett JA, Abman SH, Steinhorn RH, et al. . Bronchopulmonary dysplasia. Nat Rev Dis Primers. (2019) 5:78. 10.1038/s41572-019-0127-7 - DOI - PMC - PubMed

[4] Thébaud B, Goss KN, Laughon M, Whitsett JA, Abman SH, Steinhorn RH, et al. . Bronchopulmonary dysplasia. Nat Rev Dis Primers. (2019) 5:78. 10.1038/s41572-019-0127-7 - DOI - PMC - PubMed

[5] Ambalavanan N, Walsh M, Bobashev G, Das A, Levine B, Carlo WA, et al. . Intercenter differences in bronchopulmonary dysplasia or death among very low birth weight infants. Pediatrics. (2011) 127:e106–16. 10.1542/peds.2010-0648 - DOI - PMC - PubMed

[6] Ambalavanan N, Walsh M, Bobashev G, Das A, Levine B, Carlo WA, et al. . Intercenter differences in bronchopulmonary dysplasia or death among very low birth weight infants. Pediatrics. (2011) 127:e106–16. 10.1542/peds.2010-0648 - DOI - PMC - PubMed

[7] Stoll BJ, Hansen NI, Bell EF, Shankaran S, Laptook AR, Walsh MC, et al. . Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network. Pediatrics. (2010) 126:443–56. 10.1542/peds.2009-2959 - DOI - PMC - PubMed

[8] Stoll BJ, Hansen NI, Bell EF, Shankaran S, Laptook AR, Walsh MC, et al. . Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network. Pediatrics. (2010) 126:443–56. 10.1542/peds.2009-2959 - DOI - PMC - PubMed

[9] Davidson LM, Berkelhamer SK. Bronchopulmonary dysplasia: chronic lung disease of infancy and long-term pulmonary outcomes. J Clin Med. (2017) 6:4. 10.3390/jcm6010004 - DOI - PMC - PubMed

[10] Davidson LM, Berkelhamer SK. Bronchopulmonary dysplasia: chronic lung disease of infancy and long-term pulmonary outcomes. J Clin Med. (2017) 6:4. 10.3390/jcm6010004 - DOI - PMC - PubMed

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The Relationship Between Cord Blood Cytokine Levels and Perinatal Characteristics and Bronchopulmonary Dysplasia: A Case-Control Study

Affiliations

The Relationship Between Cord Blood Cytokine Levels and Perinatal Characteristics and Bronchopulmonary Dysplasia: A Case-Control Study

Authors

Affiliations

Abstract

Conflict of interest statement

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Abstract

Conflict of interest statement

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