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. 2022 Apr 7:10:847864.
doi: 10.3389/fped.2022.847864. eCollection 2022.

Chemotherapy Combined With Surgery in a Case With Metanephric Adenoma

Shaohua Hu  1 , Zhenli Zhao  1 , Zhisheng Wan  1 , Weizhen Bu  1 , Songqiang Chen  1 , Yiqun Lu  2
Affiliations

Chemotherapy Combined With Surgery in a Case With Metanephric Adenoma

Shaohua Hu et al. Front Pediatr. .

Abstract

Background: Metanephric adenoma is an extremely rare renal neoplasm, especially in pediatrics. Chemotherapy combined with surgery in metanephric adenoma has not been reported.

Methods: We describe a case of metanephric adenoma in a child less than 2 years old, which were treated by chemotherapy combined with surgery.

Results: Nephron sparing surgery was performed after regular chemotherapy, and the pathological result was metanephric adenoma.

Conclusion: Pediatric metanephric adenoma is extremely rare; the clinical manifestations and imaging examinations lack specificity. Nephron sparing surgery is recommended as the preferred treatment for metanephric adenoma. Long-term follow-up and more in-depth molecular genetic research are still needed to determine the benign or malignant of metanephric adenoma and whether chemotherapy drugs have an effect on it.

Keywords: chemotherapeutics; children; metanephric adenoma; nephron sparing surgery; operation treatment.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
(A) CT plain scan before chemotherapy: CT value was 46 HU. (B) CT enhanced before chemotherapy: the third stage showed obvious uneven enhancement, with CT values of about 58 HU, 98 HU, and 133 HU, respectively.
FIGURE 2
FIGURE 2
(A) MRI plain scan before chemotherapy: equisignal on T1WI, slightly higher signal on T2WI, significantly higher signal on DWI, and low signal on ADC. (B) MRI enhancement before chemotherapy: dynamic enhancement showed delayed uneven enhancement, and the degree was weaker than that of renal cortex.
FIGURE 3
FIGURE 3
(A) CT plain scan after chemotherapy: CT value was 43HU. (B) CT enhanced after chemotherapy: the third stage showed obvious uneven enhancement, with CT values of about 63HU, 101HU, and 135HU, respectively.
FIGURE 4
FIGURE 4
Microscopic appearance of the metanephric adenoma (HE 10 × 10).
See this image and copyright information in PMC

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