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. 1987 Feb;40(2):143-6.
doi: 10.1136/jcp.40.2.143.

Immunohistological detection of Legionella pneumophila in lung sections

J M Theaker, J O Tobin, S E Jones, P Kirkpatrick, M I Vina, K A Fleming

Immunohistological detection of Legionella pneumophila in lung sections

J M Theaker et al. J Clin Pathol. 1987 Feb.

Abstract

Immunohistology was used for the detection of Legionella pneumophila serogroup I in necropsy tissue. Study of pneumonic lung from the recent Stafford outbreak has shown that this technique has a high sensitivity. A retrospective postmortem examination showed that L pneumophila serogroup 1 was an unusual cause of pneumonia in Oxfordshire during the study period. L pneumophila serogroup 1 can be successfully subgrouped, using a panel of monoclonal antibodies on formalin fixed paraffin embedded sections. Immunohistological methods have a potentially useful role in the diagnosis of Legionellosis at postmortem examination and in the epidemiological investigation of individual cases and outbreaks.

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