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Editorial
. 2022 Apr;11(2):288-291.
doi: 10.21037/hbsn-21-521.

Commentary on "The tumour microenvironment shapes innate lymphoid cells in patients with hepatocellular carcinoma"

Li-Hong He #  1   2   3   4   5 , Xiao-Zhen Zhang #  1   2   3   4   5 , Kang Sun  1   2   3   4   5 , Xue-Li Bai  1   2   3   4   5
Affiliations
Editorial

Commentary on "The tumour microenvironment shapes innate lymphoid cells in patients with hepatocellular carcinoma"

Li-Hong He et al. Hepatobiliary Surg Nutr. 2022 Apr.
No abstract available

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Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://hbsn.amegroups.com/article/view/10.21037/hbsn-21-521/coif). The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
A schematic model depicting the plasticity of ILCs and related regulatory cytokines in the HCC tumor microenvironment. The plasticity of ILCs in the non-tumor, margin, and tumor microenvironments in HCC is enlarged and shown in three figures. The black arrows point in the direction of potential plasticity. The figure in the right half shows the direction of plasticity of the ILCs and their regulatory cytokines in the entire HCC microenvironment. IL-1β, IL-15, IL-23, and TGF-β may promote plasticity from NK-like cells to ILC1, while IL-33, IL-4, and IL-6 may activate ILC2 as well as promote plasticity of ILC3/1 to ILC2. An increased proportion of activated ILC2 may perform two opposite functions of reducing or improving survival in HCC via the “CXCL2-neutrophils” axis and potential cross-talk with other immune cells, respectively. ILCs, innate lymphoid cells; HCC, hepatocellular carcinoma; IL, interleukin; NK, natural killer; TGF, transforming growth factor; CD, cluster of differentiation; CXCL2, C-X-C motif chemokine ligand 2.
See this image and copyright information in PMC

Comment on

  • The tumour microenvironment shapes innate lymphoid cells in patients with hepatocellular carcinoma.
    Heinrich B, Gertz EM, Schäffer AA, Craig A, Ruf B, Subramanyam V, McVey JC, Diggs LP, Heinrich S, Rosato U, Ma C, Yan C, Hu Y, Zhao Y, Shen TW, Kapoor V, Telford W, Kleiner DE, Stovroff MK, Dhani HS, Kang J, Fishbein T, Wang XW, Ruppin E, Kroemer A, Greten TF, Korangy F. Heinrich B, et al. Gut. 2022 Jun;71(6):1161-1175. doi: 10.1136/gutjnl-2021-325288. Epub 2021 Aug 2. Gut. 2022. PMID: 34340996 Free PMC article.

References

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