Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Apr-Jun;13(2):83-88.
doi: 10.4103/japtr.japtr_292_21. Epub 2022 Apr 7.

Antihyperlipidemic, anti-inflammatory, analgesic, and antipyretic activities of "dimethyl dimethoxy biphenyl dicarboxylate" in male Wistar rats

Heba M I Abdallah  1 , Gihan F Asaad  1 , Mahmoud S Arbid  1 , Yousra A Nomier  2
Affiliations

Antihyperlipidemic, anti-inflammatory, analgesic, and antipyretic activities of "dimethyl dimethoxy biphenyl dicarboxylate" in male Wistar rats

Heba M I Abdallah et al. J Adv Pharm Technol Res. 2022 Apr-Jun.

Abstract

Dimethyl dimethoxy biphenyl (DDB) dicarboxylate has been applied as a therapeutic modality for curing liver diseases, particularly hepatitis virus. The objective of this study was to assess the protective potential against Triton X-100 induced abnormal fat metabolism in addition to anti-inflammatory, analgesic, and antipyretic effects of DDB. The anti-inflammatory, antinociceptive, and antipyretic of DDB were investigated through induction of paw edema, pain, and fever in experimental rats. DDB decreased cholesterol and triglyceride contents. DDB resulted in inhibition of inflammation, nociception, and fever in the experimental models. DDB improved lipid profile, as evidence of hypolipidemic potential. It also showed anti-inflammatory, analgesic, and antipyretic properties.

Keywords: Analgesic; Triton X-100; anti-inflammatory; antihyperlipidemic; antipyretic; dimethyl dimethoxy biphenyl dicarboxylate.

PubMed Disclaimer

Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Results (mean ± SE) (n = 6), aP < 0.05 was representing significance. aP < 0.05 versus control group, bP < 0.05 versus Triton X-100
Figure 2
Figure 2
Results are mean ± SE. (n = 6), aP value of < 0.05 was representing significance. aP < 0.05 versus control group, bP < 0.05 versus Triton X-100
Figure 3
Figure 3
Effect of dimethyl dimethoxy biphenyl on liver histopathology. Normal control group (3a), Triton X-100 group (3b) and DDP+ Triton X-100 group (3c)
Figure 4
Figure 4
Results are mean ± SE. (n = 6), aP < 0.05 was representing significance. aP < 0.05 versus control group, bP < 0.05 versus tramadol
Figure 5
Figure 5
Results are mean ± SE. (n = 6), aP < 0.05 was representing significance. aP < 0.05 versus control group, bP < 0.05 versus paracetamol
See this image and copyright information in PMC

References

    1. Sudha SS, Karthic R, Rengaramanujam J. Anti hyperlipidemic activity of Spirulina platensis in Triton x-100 induced hyperlipidemic rats. Hygeia J Drugs Med. 2011;3:32–7.
    1. Woo MN, Bok SH, Choi MS. Hypolipidemic and body fat-lowering effects of Fatclean in rats fed a high-fat diet. Food Chem Toxicol. 2009;47:2076–82. - PubMed
    1. Cox RA, Garcia-Palmieri MR. Cholesterol, Triglycerides, and Associated Lipoproteins. In: Walker HK, Hall WD, Hurst JW, editors. Clinical Methods: The History, Physical, and Laboratory Examinations. 1990.
    1. Gundamaraju R, Hwi KK, Singla RK, Vemuri RC, Mulapalli SB. Antihyperlipidemic potential of Albizia amara (Roxb) Boiv.bark against Triton X-100 induced hyperlipidemic condition in rats. Pharmacognosy Res. 2014;6:267–73. - PMC - PubMed
    1. Golomb BA, Evans MA. Statin adverse effects: A review of the literature and evidence for a mitochondrial mechanism. Am J Cardiovasc Drugs. 2008;8:373–418. - PMC - PubMed