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Review
. 2022 Apr 8:3:859209.
doi: 10.3389/froh.2022.859209. eCollection 2022.

The Microbiome in Periodontitis and Diabetes

Davi Neto de Araújo Silva  1 , Maísa Casarin  2 , Sepehr Monajemzadeh  1 , Beatriz de Brito Bezerra  1 , Renate Lux  1 , Flavia Q Pirih  1
Affiliations
Review

The Microbiome in Periodontitis and Diabetes

Davi Neto de Araújo Silva et al. Front Oral Health. .

Abstract

Objectives: To perform a comprehensive and integrative review of the available literature on the potential changes in the microbiome of healthy and individuals with diabetes under periodontal health and disease.

Materials and methods: The review was conducted by two independent reviewers. Indexed electronic databases (PubMed/Medline, Cochrane Library, Web of Science and Scopus) were searched, including articles published in English and dated from 5 years ago until December 2021. A manual search also was performed to identify co-related articles. Following the removal of duplicates and eligibility criteria, the articles were included in tables for analysis and described in the manuscript.

Results: According to this review, diabetes mellitus was associated with significant changes in the subgingival and salivary microbiome, either in its association with periodontitis or in cases of periodontal health. In addition to affecting microbial diversity in terms of taxonomy, metagenomic studies have shown that this endocrine disorder may also be directly related to increased pathogenicity in the oral microbiome.

Conclusion: Although the reviewed studies demonstrate important differences in the subgingival and salivary microbiome composition because of diabetes mellitus, further studies are needed to clarify the real effects of hyperglycemia on oral microbial profiles and support new diagnostic approaches and innovative treatments.

Keywords: diabetes mellitus; genetics; integrative review; oral microbiome; periodontitis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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References

    1. Papapanou PN, Sanz M, Buduneli N, Dietrich T, Feres M, Fine DH, et al. . Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Periodontol. (2018) 89 Suppl 1:S173–82. 10.1002/JPER.17-0721 - DOI - PubMed
    1. Cho NH, Shaw JE, Karuranga S, Huang Y, da Rocha Fernandes JD, Ohlrogge AW, et al. . IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Res Clin Pract. (2018) 138:271–81. 10.1016/j.diabres.2018.02.023 - DOI - PubMed
    1. Tsalamandris S, Antonopoulos AS, Oikonomou E, Papamikroulis GA, Vogiatzi G, Papaioannou S, et al. . The role of inflammation in diabetes: Current concepts and future perspectives. Eur Cardiol. (2019) 14:50–9. 10.15420/ecr.2018.33.1 - DOI - PMC - PubMed
    1. Brennan DS, Spencer AJ, Roberts-Thomson KF. Quality of life and disability weights associated with periodontal disease. J Dent Res. (2007) 86:713–7. 10.1177/154405910708600805 - DOI - PubMed
    1. Kassebaum NJ, Bernabe E, Dahiya M, Bhandari B, Murray CJ, Marcenes W. Global burden of severe periodontitis in 1990-2010: a systematic review and meta-regression. J Dent Res. (2014) 93:1045–53. 10.1177/0022034514552491 - DOI - PMC - PubMed

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