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Review
. 2022 May;40(2):437-453.
doi: 10.1016/j.ncl.2021.11.003. Epub 2022 Mar 31.

Surgical Neuro-Oncology: Management of Glioma

Dana Mitchell  1 , Jack M Shireman  2 , Mahua Dey  3
Affiliations
Review

Surgical Neuro-Oncology: Management of Glioma

Dana Mitchell et al. Neurol Clin. 2022 May.

Abstract

Gliomas are the most common intrinsic brain tumor in adults. Although maximal tumor resection improves survival, this must be balanced with preservation of neurologic function. Technological advancements have greatly expanded our ability to safely maximize tumor resection and design innovative therapeutic trials that take advantage of intracavitary delivery of therapeutic agents after resection. In this article, we review the role of surgical intervention for both low-grade and high-grade gliomas and the innovations that are driving and expanding the role of surgery in this therapeutically challenging group of malignancies.

Keywords: Astrocytoma; Biopsy; Glioblastoma; Glioma; Low-grade glioma; Management; Oligodendroglioma; Surgery.

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Conflict of interest statement

Disclosure Statement: Authors declare no conflict of Interest.

Figures

Figure 1:
Figure 1:. MRI imaging showing differences between low and high grade gliomas:
A) Axial T1 with contrast, B) axial FLAIR and C) axial T2 shows a non-enhancing right frontal lesion. D) Axial T1 with contrast, E) axial FLAIR and F) axial T2 shows a ring enhancing left temporal lesion.
Figure 2:
Figure 2:. fMRI and DTI imaging:
A) Axial & B) sagittal FLAIR sequencing demonstrating left temporal lesion with functional mapping. C) Tractography shows the relationship of major tracts in relation to the lesion.
Figure 3:
Figure 3:. Intraoperative monitoring:
A) Intraoperative monitoring of motor evoked potential B) Intra-operative strip placement for motor mapping via DCS.
See this image and copyright information in PMC

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