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Review
. 1987 Jan;234(1):1-8.
doi: 10.1007/BF00314000.

Antifibrinolytic agents in subarachnoid haemorrhage

K W Lindsay
Review

Antifibrinolytic agents in subarachnoid haemorrhage

K W Lindsay. J Neurol. 1987 Jan.

Abstract

For many years clinicians have used antifibrinolytic agents to try to reduce rebleeding after subarachnoid haemorrhage. Early studies of their effectiveness produced conflicting results. This paper re-evaluates the available trials and considers benefits in the light of potential complications. Present evidence conclusively demonstrates that epsilon-aminocaproic acid and tranexamic acid administered in standard dosage, reduce the risk of rebleeding but, as a result of an increased incidence of ischaemic complications, do not benefit patients' outcome.

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