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. 2022 Jul;49(7):6971-6973.
doi: 10.1007/s11033-022-07464-4. Epub 2022 Apr 25.

Non-coding RNAs: the silent regulators of health and diseases

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Non-coding RNAs: the silent regulators of health and diseases

Nishant Chakravorty. Mol Biol Rep. 2022 Jul.

Abstract

Non-coding RNAs (ncRNAs) like miRNAs, siRNA, lncRNAs, circRNAs, piRNAs, snoRNAs, snRNAs etc. form a collective group of RNAs that is instrumental to the various functions of the genome. With the advent of cutting-edge molecular biology tools and techniques, scientists have unearthed several mechanisms through which these ncRNAs act. Although our understanding may still be limited, yet scientists have been able to establish ncRNAs as major regulators of genetic inter-plays that dictate various pathophysiological conditions. This special issue of Molecular Biology Reports features a collection of research and review articles on ncRNAs and their involvement in different pathophysiological conditions that include different types of cancers. It is expected that this special issue will motivate researchers in the field to delve deeper into the world of ncRNAs and attempt to develop new diagnostic and therapeutic interventions for challenging clinical conditions.

Keywords: Non-coding RNAs; lncRNA; miRNA; ncRNA; piRNA; siRNA.

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Conflict of interest statement

The author has no relevant financial or non-financial interests to disclose.

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References

    1. Palazzo AF, Koonin EV. Functional long non-coding RNAs evolve from junk transcripts. Cell. 2020;183:1151–1161. doi: 10.1016/j.cell.2020.09.047. - DOI - PubMed
    1. Graur D, Zheng Y, Azevedo RB. An evolutionary classification of genomic function. Genome Biol Evol. 2015;642:645. doi: 10.1093/gbe/evv021. - DOI - PMC - PubMed
    1. ENCODE Project Consortium An integrated encyclopedia of DNA elements in the human genome. Nature. 2012;489(7414):57–74. doi: 10.1038/nature11247. - DOI - PMC - PubMed
    1. Doolittle WF. Is junk DNA bunk? A critique of ENCODE. Proc Natl Acad Sci USA. 2013;110(14):5294–5300. doi: 10.1073/pnas.1221376110. - DOI - PMC - PubMed
    1. Palazzo AF, Lee ES. Non-coding RNA: what is functional and what is junk? Front Genet. 2015 doi: 10.3389/fgene.2015.00002.PMID:25674102;PMCID:PMC4306305. - DOI - PMC - PubMed

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