Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jun 1;65(2):388-396.
doi: 10.1097/GRF.0000000000000698. Epub 2022 Apr 11.

Impact of Prenatal Exposure to Smoking on Child Health

Michelle C Maciag  1   2   3 , Aroub Yousuf  4 , Marissa Hauptman  3   5   6
Affiliations

Impact of Prenatal Exposure to Smoking on Child Health

Michelle C Maciag et al. Clin Obstet Gynecol. .

Abstract

Prenatal exposure to tobacco smoke remains common, through active smoking and/or passive environmental exposure, and is linked to adverse childhood outcomes. Not only have high-quality studies and meta-analyses demonstrated increased risks of prenatal as well as postnatal complications, but adverse child outcomes are well described. In utero exposure to tobacco smoke has been associated with congenital anomalies, infant and teenager overweight and obesity, and neuropsychiatric sequelae. In addition, certain childhood malignancies have been linked to paternal smoking during pregnancy. In this chapter, adverse childhood outcomes related to intrauterine exposure to electronic cigarettes and marijuana are described.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest Disclosures: The authors have no example of conflict of interests to disclose.

Figures

Figure I:
Figure I:
Overview of Childhood Outcomes Associated with Tobacco Smoke Exposure During Pregnancy
Figure II:
Figure II:
Chemicals reported in aerosols, refill solutions and cartridges of e-cigarettes List of chemicals as reported in: Cheng T. Chemical evaluation of electronic cigarettes. Tob Control. 2014;23 Suppl 2(Suppl 2):ii11-ii17. doi:10.1136/tobaccocontrol-2013-051482
See this image and copyright information in PMC

References

    1. McEvoy CT, Spindel ER. Pulmonary Effects of Maternal Smoking on the Fetus and Child: Effects on Lung Development, Respiratory Morbidities, and Life Long Lung Health. Paediatr Respir Rev 2017; 21:27–33. - PMC - PubMed
    1. Thacher JD, Gehring U, Gruzieva O, Standl M, Pershagen G, Bauer CP, et al. Maternal Smoking during Pregnancy and Early Childhood and Development of Asthma and Rhinoconjunctivitis - a MeDALL Project. Environ Health Perspect 2018; 126:047005. - PMC - PubMed
    1. Murin S, Rafii R, Bilello K. Smoking and smoking cessation in pregnancy. Clin Chest Med 2011; 32:75–91. - PubMed
    1. Carpinello OJ, DeCherney AH, Hill MJ. Developmental Origins of Health and Disease: The History of the Barker Hypothesis and Assisted Reproductive Technology. Semin Reprod Med 2018; 36:177–82. - PubMed
    1. Slotkin TA, Tate CA, Cousins MM, Seidler FJ. Prenatal nicotine exposure alters the responses to subsequent nicotine administration and withdrawal in adolescence: Serotonin receptors and cell signaling. Neuropsychopharmacology 2006; 31:2462–75. - PubMed

Publication types

Substances