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Editorial
. 2022 Apr 26;145(17):1356-1358.
doi: 10.1161/CIRCULATIONAHA.122.059106. Epub 2022 Apr 25.

At the Brink of Human Therapy to Generate New Myocytes in the Adult Injured Heart

Vikram Prasad  1 , Jeffery D Molkentin  1
Affiliations
Editorial

At the Brink of Human Therapy to Generate New Myocytes in the Adult Injured Heart

Vikram Prasad et al. Circulation. .
No abstract available

Keywords: Editorials; cell cycle; cell proliferation; myocytes, cardiac.

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Comment on

  • Transient Cell Cycle Induction in Cardiomyocytes to Treat Subacute Ischemic Heart Failure.
    Abouleisa RRE, Salama ABM, Ou Q, Tang XL, Solanki M, Guo Y, Nong Y, McNally L, Lorkiewicz PK, Kassem KM, Ahern BM, Choudhary K, Thomas R, Huang Y, Juhardeen HR, Siddique A, Ifthikar Z, Hammad SK, Elbaz AS, Ivey KN, Conklin DJ, Satin J, Hill BG, Srivastava D, Bolli R, Mohamed TMA. Abouleisa RRE, et al. Circulation. 2022 Apr 26;145(17):1339-1355. doi: 10.1161/CIRCULATIONAHA.121.057641. Epub 2022 Jan 21. Circulation. 2022. PMID: 35061545 Free PMC article.

References

    1. Kretzschmar K, Post Y, Bannier-Hélaouët M, Mattiotti A, Drost J, Basak O, Li VSW, van den Born M, Gunst QD, Versteeg D, Kooijman L, van der Elst S, van Es JH, van Rooij E, van den Hoff MJB, Clevers H. Profiling proliferative cells and their progeny in damaged murine hearts. Proc Natl Acad Sci U S A. 2018;115:E12245–E12254. - PMC - PubMed
    1. Adler CP, Friedburg H, Herget GW, Neuburger M, Schwalb H. Variability of cardiomyocyte DNA content, ploidy level and nuclear number in mammalian hearts. Virchows Arch. 1996;429:159–64. - PubMed
    1. Derks W, Bergmann O. Polyploidy in Cardiomyocytes: Roadblock to Heart Regeneration? Circ Res. 2020;126:552–565. - PubMed
    1. Lázár E, Sadek HA, Bergmann O. Cardiomyocyte renewal in the human heart: insights from the fall-out. Eur Heart J. 2017;38:2333–2342. - PMC - PubMed
    1. Johnson J, Mohsin S, Houser SR. Cardiomyocyte Proliferation as a Source of New Myocyte Development in the Adult Heart. Int J Mol Sci. 2021;22:7764. - PMC - PubMed