[Diagnosing Alzheimer's dementia - a playground for academics or a sensible clinical measure?]

Abstract

The number of dementia cases continues to increase with Alzheimer's disease as the leading cause. The diagnostic workup of Alzheimer's dementia is complex, and its clinical relevance debatable considering the current lack of disease-modifying treatments. From this perspective, a stepwise diagnostic approach is recommended. Whenever Alzheimer's dementia is suspected, a patient' history a physical and psychiatric examination, neuropsychological tests, routine blood tests and standard cerebral imaging should be conducted. This allows in many cases a diagnosis to be given. In cases remaining unclear, modern biomarker tests are proving increasingly useful. Knowledge of the diagnosis is pivotal for the patients to assess the prognosis, to enable them to make plans for their future and to get access to available treatment. The approval of aducanumab in the USA and other promising monoclonal antibodies currently in phase 3-trials as well as the development of blood biomarkers give us hope for the future.